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    MUC13 mucin 13, cell surface associated [ Homo sapiens (human) ]

    Gene ID: 56667, updated on 28-Oct-2024

    Summary

    Official Symbol
    MUC13provided by HGNC
    Official Full Name
    mucin 13, cell surface associatedprovided by HGNC
    Primary source
    HGNC:HGNC:7511
    See related
    Ensembl:ENSG00000173702 MIM:612181; AllianceGenome:HGNC:7511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRCC1; MUC-13
    Summary
    Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 317.3), small intestine (RPKM 271.9) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MUC13 in Genome Data Viewer
    Location:
    3q21.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (124905442..124934751, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (127630861..127660325, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (124624289..124653595, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene integrin subunit beta 5 Neighboring gene uncharacterized LOC124906277 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124545465-124546128 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:124546129-124546792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124548121-124548784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124548785-124549448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124552923-124553422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20406 Neighboring gene Sharpr-MPRA regulatory region 831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124561149-124561650 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124561651-124562150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:124564159-124564658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124577655-124578192 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124587550-124588050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124588051-124588551 Neighboring gene Sharpr-MPRA regulatory region 8988 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:124604052-124604936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14655 Neighboring gene enolase 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14656 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:124606705-124607587 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:124607588-124608472 Neighboring gene NANOG hESC enhancer GRCh37_chr3:124626617-124627118 Neighboring gene Sharpr-MPRA regulatory region 13474 Neighboring gene heart development protein with EGF like domains 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:124720175-124721374 Neighboring gene Sharpr-MPRA regulatory region 1791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:124762717-124763230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14657 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20409 Neighboring gene RNA, 5S ribosomal pseudogene 137

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of gastrointestinal epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    mucin-13
    Names
    down-regulated in colon cancer 1
    mucin 13, epithelial transmembrane

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033049.4NP_149038.3  mucin-13 precursor

      See identical proteins and their annotated locations for NP_149038.3

      Status: VALIDATED

      Source sequence(s)
      AB035807, AF286113, AK000070, DA428072
      Consensus CDS
      CCDS33839.2
      UniProtKB/Swiss-Prot
      Q6UWD9, Q9H3R2, Q9NXT5
      Related
      ENSP00000485028.1, ENST00000616727.4
      Conserved Domains (2) summary
      TIGR04561
      Location:419468
      membra_charge; integral membrane protein
      pfam01390
      Location:214313
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      124905442..124934751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      127630861..127660325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)