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    NOLC1 nucleolar and coiled-body phosphoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 9221, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NOLC1provided by HGNC
    Official Full Name
    nucleolar and coiled-body phosphoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:15608
    See related
    Ensembl:ENSG00000166197 MIM:602394; AllianceGenome:HGNC:15608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P130; Srp40; NOPP130; NOPP140; NS5ATP13
    Summary
    Enables molecular function inhibitor activity; protein heterodimerization activity; and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Acts upstream of or within axonogenesis and regulation of synaptic plasticity. Located in fibrillar center. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NOLC1 in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102152389..102163870)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103037369..103048850)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103912146..103923627)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2738 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103867277-103867778 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103870016-103871215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103876901-103877603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103877604-103878305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2745 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103880011-103880762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103880763-103881514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103881515-103882264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103887116-103887946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2750 Neighboring gene LIM domain binding 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103897995-103899194 Neighboring gene PPARG related coactivator 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103911632-103912831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2751 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:103989615-103989783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2754 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired like homeodomain 3 Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Roles of NOLC1 in cancers and viral infection. Zhai F, et al. J Cancer Res Clin Oncol, 2023 Sep. PMID 37296317
    2. Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells. Huang H, et al. Cell Mol Biol Lett, 2018. PMID 30505321, Free PMC Article
    3. Localization of Nopp140 within mammalian cells during interphase and mitosis. Thiry M, et al. Histochem Cell Biol, 2009 Aug. PMID 19381672, Free PMC Article
    4. NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and β-catenin accumulation. Kim W, et al. Biochem Biophys Res Commun, 2022 Dec 20. PMID 36265288
    5. The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy. Renvoisé B, et al. Hum Mol Genet, 2009 Apr 1. PMID 19129172, Free PMC Article

    See all (201) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of the Nonstructural Protein-Nucleolar and Coiled-Body Phosphoprotein 1 Protein Interaction on rRNA Synthesis Through Telomeric Repeat-Binding Factor 2 Regulation Under Nucleolar Stress.
      Title: Effects of the Nonstructural Protein-Nucleolar and Coiled-Body Phosphoprotein 1 Protein Interaction on rRNA Synthesis Through Telomeric Repeat-Binding Factor 2 Regulation Under Nucleolar Stress.
    2. T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.
      Title: T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.
    3. High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer.
      Title: High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer.
    4. Roles of NOLC1 in cancers and viral infection.
      Title: Roles of NOLC1 in cancers and viral infection.
    5. NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and beta-catenin accumulation.
      Title: NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and β-catenin accumulation.
    6. Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.
      Title: Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.
    7. This study suggests that the dynamic distribution of telomerase between Cajal bodies and nucleoplasm uniquely impacts telomere length maintenance and identifies Nopp140 as a novel player in telomere biology.
      Title: Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length.
    8. Nucleolar TRF2 attenuated nucleolus stress-induced hepatocellular carcinoma cell-cycle arrest by altering rRNA synthesis via interaction with NOLC1.
      Title: Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis.
    9. Identification and validation of NOLC1 might be a promising therapeutic strategy for the management of multidrug resistance of non-small cell lung cancer patients.
      Title: Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells.
    10. In this study, the disordered feature of Nopp140 and the effect of CK2alpha on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR).
      Title: Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA is identified to have a physical interaction with nucleolar and coiled-body phosphoprotein 1 (NOLC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0035

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables molecular function inhibitor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural crest formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolus organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar and coiled-body phosphoprotein 1
    Names
    140 kDa nucleolar phosphoprotein
    HCV NS5A trans-regulated protein 13
    HCV NS5A-transactivated protein 13
    hepatitis C virus NS5A-transactivated protein 13
    nucleolar 130 kDa protein
    nucleolar and coiled-body phosphprotein 1
    nucleolar phosphoprotein p130
    nucleolar protein p130

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284388.2 → NP_001271317.1  nucleolar and coiled-body phosphoprotein 1 isoform 1

      See identical proteins and their annotated locations for NP_001271317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK314363, AL520884, D21262, DA588285
      Consensus CDS
      CCDS65926.1
      UniProtKB/TrEMBL
      A0A0A0MRM9
      Related
      ENSP00000359024.5, ENST00000370007.5
      Conserved Domains (1) summary
      pfam05022
      Location:634 → 700
      SRP40_C; SRP40, C-terminal domain

    2. NM_001284389.2 → NP_001271318.1  nucleolar and coiled-body phosphoprotein 1 isoform 3

      See identical proteins and their annotated locations for NP_001271318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL520884, BC001883, D21262, DA588285
      Consensus CDS
      CCDS65925.1
      UniProtKB/TrEMBL
      B2RAU8
      Related
      ENSP00000475080.1, ENST00000488254.6
      Conserved Domains (1) summary
      pfam05022
      Location:625 → 691
      SRP40_C; SRP40, C-terminal domain

    3. NM_004741.5 → NP_004732.2  nucleolar and coiled-body phosphoprotein 1 isoform 2

      See identical proteins and their annotated locations for NP_004732.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK314363, AL520884, BC006769
      Consensus CDS
      CCDS7530.1
      UniProtKB/Swiss-Prot
      Q14978, Q15030, Q5VV70, Q9BUV3
      UniProtKB/TrEMBL
      B2RAU8
      Related
      ENSP00000474710.2, ENST00000605788.6
      Conserved Domains (1) summary
      pfam05022
      Location:624 → 690
      SRP40_C; SRP40, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      102152389..102163870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270273.3 → XP_005270330.1  nucleolar and coiled-body phosphoprotein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MRM9
      Conserved Domains (1) summary
      pfam05022
      Location:635 → 701
      SRP40_C; SRP40, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      103037369..103048850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367144.1 → XP_054223119.1  nucleolar and coiled-body phosphoprotein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14978.2 GenPept UniProtKB/Swiss-Prot:Q14978

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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