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    TPRA1 transmembrane protein adipocyte associated 1 [ Homo sapiens (human) ]

    Gene ID: 131601, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TPRA1provided by HGNC
    Official Full Name
    transmembrane protein adipocyte associated 1provided by HGNC
    Primary source
    HGNC:HGNC:30413
    See related
    Ensembl:ENSG00000163870 MIM:608336; AllianceGenome:HGNC:30413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR175; TPRA40; TMEM227
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 7.3), endometrium (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TPRA1 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (127571232..127598231, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (130305897..130332949, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127290075..127317074, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2016 Neighboring gene uncharacterized LOC105374094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127110535-127111346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127113684-127114550 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:127121540-127122739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20456 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:127171391-127171911 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127184463-127184964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127184965-127185464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127191951-127192452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127192453-127192952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:127212327-127213012 Neighboring gene long intergenic non-protein coding RNA 1471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14687 Neighboring gene long intergenic non-protein coding RNA 2034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127293720-127294299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127294300-127294878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127298480-127299441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127307841-127308518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127308519-127309195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127316932-127317889 Neighboring gene microRNA 6825 Neighboring gene microRNA 7976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127335678-127336178 Neighboring gene uncharacterized LOC107986126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20458 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127357688-127358188 Neighboring gene podocalyxin like 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:127386638-127386819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14695

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. Singh J, et al. J Biol Chem, 2015 Dec 4. PMID 26451044, Free PMC Article
    2. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. Yang H, et al. Endocrinology, 1999 Jun. PMID 10342878
    3. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Büssow K, et al. Nucleic Acids Res, 1998 Nov 1. PMID 9776767, Free PMC Article
    4. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. Shen C, et al. J Mol Neurosci, 2015 May. PMID 25464930
    5. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Ma J, et al. Atherosclerosis, 2007 Mar. PMID 16806233

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpr175 is a novel positive regulator of the Hh signaling pathway
      Title: The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32197

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein adipocyte-associated 1
    Names
    G protein-coupled receptor 175
    integral membrane protein GPR175
    seven transmembrane domain orphan receptor
    transmembrane domain protein regulated in adipocytes 40 kDa
    transmembrane protein 227
    transmembrane protein, adipocyte asscociated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136053.4 → NP_001129525.1  transmembrane protein adipocyte-associated 1 isoform 1

      See identical proteins and their annotated locations for NP_001129525.1

      Status: VALIDATED

      Source sequence(s)
      AC084035, BC050711, BM670609, HY066741
      Consensus CDS
      CCDS3042.1
      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Related
      ENSP00000347748.3, ENST00000355552.8
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    2. NM_001142646.4 → NP_001136118.1  transmembrane protein adipocyte-associated 1 isoform 2

      See identical proteins and their annotated locations for NP_001136118.1

      Status: VALIDATED

      Source sequence(s)
      AC084035, AF289568, BC050711, BM670609, HY066741
      Consensus CDS
      CCDS46899.1
      UniProtKB/Swiss-Prot
      Q86W33
      Related
      ENSP00000296210.7, ENST00000296210.11
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 203
      Tmemb_40; Predicted membrane protein

    3. NM_001353001.2 → NP_001339930.1  transmembrane protein adipocyte-associated 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC084035, BM670609
      Consensus CDS
      CCDS3042.1
      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    4. NM_001353002.2 → NP_001339931.1  transmembrane protein adipocyte-associated 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC084035, BM670609, CF132113
      Consensus CDS
      CCDS3042.1
      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    5. NM_001353003.2 → NP_001339932.1  transmembrane protein adipocyte-associated 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC023593, AC084035, BM670609
      Consensus CDS
      CCDS3042.1
      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    6. NM_001353004.2 → NP_001339933.1  transmembrane protein adipocyte-associated 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC023593, AC084035, BM670609
      Consensus CDS
      CCDS3042.1
      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Related
      ENSP00000498161.1, ENST00000648957.1
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    7. NM_001353005.2 → NP_001339934.1  transmembrane protein adipocyte-associated 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC023593, AC084035, BM670609
      Consensus CDS
      CCDS3042.1
      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    8. NM_001353006.2 → NP_001339935.1  transmembrane protein adipocyte-associated 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC084035, BM670609
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 166
      Tmemb_40; Predicted membrane protein

    9. NM_001353007.2 → NP_001339936.1  transmembrane protein adipocyte-associated 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC023593, AC084035, BM670609
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 275
      Tmemb_40; Predicted membrane protein

    RNA

    1. NR_073377.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084035, BC017058, BM670609, HY066741

    2. NR_148226.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084035, BM670609

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      127571232..127598231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447443.1 → XP_047303399.1  transmembrane protein adipocyte-associated 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

    2. XM_047447440.1 → XP_047303396.1  transmembrane protein adipocyte-associated 1 isoform X1

    3. XM_047447441.1 → XP_047303397.1  transmembrane protein adipocyte-associated 1 isoform X1

    4. XM_047447442.1 → XP_047303398.1  transmembrane protein adipocyte-associated 1 isoform X1

    5. XM_006713496.4 → XP_006713559.1  transmembrane protein adipocyte-associated 1 isoform X2

      See identical proteins and their annotated locations for XP_006713559.1

      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
      Related
      ENSP00000418298.1, ENST00000489960.5
      Conserved Domains (1) summary
      pfam10160
      Location:39 → 312
      Tmemb_40; Predicted membrane protein

    6. XM_047447444.1 → XP_047303400.1  transmembrane protein adipocyte-associated 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      130305897..130332949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345229.1 → XP_054201204.1  transmembrane protein adipocyte-associated 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

    2. XM_054345226.1 → XP_054201201.1  transmembrane protein adipocyte-associated 1 isoform X1

    3. XM_054345227.1 → XP_054201202.1  transmembrane protein adipocyte-associated 1 isoform X1

    4. XM_054345228.1 → XP_054201203.1  transmembrane protein adipocyte-associated 1 isoform X1

    5. XM_054345231.1 → XP_054201206.1  transmembrane protein adipocyte-associated 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

    6. XM_054345230.1 → XP_054201205.1  transmembrane protein adipocyte-associated 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016372.2: Suppressed sequence

      Description
      NM_016372.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86W33.1 GenPept UniProtKB/Swiss-Prot:Q86W33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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