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    Ano3 anoctamin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311287, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ano3provided by RGD
    Official Full Name
    anoctamin 3provided by RGD
    Primary source
    RGD:1308873
    See related
    EnsemblRapid:ENSRNOG00000004731 AllianceGenome:RGD:1308873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem16c
    Summary
    Predicted to enable intracellular calcium activated chloride channel activity and phospholipid scramblase activity. Involved in detection of mechanical stimulus and detection of temperature stimulus. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dystonia 24. Orthologous to human ANO3 (anoctamin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 215.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ano3 in Genome Data Viewer
    Location:
    3q34
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (117690242..118004695, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (97235671..97550090, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (101843516..102203368, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fin bud initiation factor homolog Neighboring gene solute carrier family 5 member 12 Neighboring gene ribosomal protein L19, pseudogene 1 Neighboring gene mucin 15, cell surface associated Neighboring gene prohibitin-2-like Neighboring gene POTE ankyrin domain family member 1 Neighboring gene olfactory receptor family 4 subfamily F member 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Wang TA, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972431, Free PMC Article
    2. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Huang F, et al. Nat Neurosci, 2013 Sep. PMID 23872594, Free PMC Article
    3. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Scudieri P, et al. Exp Physiol, 2012 Feb. PMID 21984732
    4. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
      Title: TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
    2. This study thus reveals that TMEM16C enhances K(Na) channel activity in DRG neurons and regulates the processing of pain messages.
      Title: TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium activated galactosylceramide scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within plasma membrane phospholipid scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-3
    Names
    transmembrane protein 16C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430402.1 → NP_001417331.1  anoctamin-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1M0A0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      117690242..118004695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106460.2 → XP_038962388.1  anoctamin-3 isoform X1

      Related
      ENSRNOP00000006349.7, ENSRNOT00000006349.8
      Conserved Domains (2) summary
      pfam04547
      Location:384 → 949
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:157 → 381
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. XM_039106461.2 → XP_038962389.1  anoctamin-3 isoform X2

      Conserved Domains (2) summary
      pfam04547
      Location:238 → 803
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:11 → 235
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
    Nucleotide Protein Strain
    Heading Accession and Version

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