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    Msl3 MSL complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317464, updated on 17-Aug-2024

    Summary

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    Symbol
    Msl3provided by RGD
    Full Name
    MSL complex subunit 3provided by RGD
    Primary source
    RGD:1549763
    See related
    EnsemblRapid:ENSRNOG00000004016 AllianceGenome:RGD:1549763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Msl31; Msl3l1
    Summary
    Predicted to enable DNA binding activity; histone acetyltransferase activity (H4-K16 specific); and methylated histone binding activity. Predicted to be involved in histone modification and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 190.7), Heart (RPKM 188.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (29210388..29228060)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (25638029..25655698)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (27015826..27033562)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 6 Neighboring gene uncharacterized LOC120099231 Neighboring gene uncharacterized LOC120099222 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene FERM and PDZ domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Basilicata MF, et al. Nat Genet, 2018 Oct. PMID 30224647, Free PMC Article
    2. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Kim D, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20657587, Free PMC Article
    3. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    male-specific lethal 3 homolog
    Names
    male-specific lethal-3 homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014111.1 → NP_001014133.1  male-specific lethal 3 homolog

      See identical proteins and their annotated locations for NP_001014133.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086548
      UniProtKB/TrEMBL
      Q5RJQ2
      Related
      ENSRNOP00000061187.3, ENSRNOT00000065814.3
      Conserved Domains (2) summary
      pfam05712
      Location:107 → 447
      MRG; MRG
      pfam12258
      Location:254 → 353
      Microcephalin; Microcephalin protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      29210388..29228060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602075.3 → XP_017457564.1  male-specific lethal 3 homolog isoform X8

    2. XM_063280078.1 → XP_063136148.1  male-specific lethal 3 homolog isoform X10

      UniProtKB/TrEMBL
      F7FM67

    3. XM_017602077.3 → XP_017457566.1  male-specific lethal 3 homolog isoform X9

    4. XM_063280079.1 → XP_063136149.1  male-specific lethal 3 homolog isoform X11

    5. XM_008773169.4 → XP_008771391.2  male-specific lethal 3 homolog isoform X1

    6. XM_006256835.5 → XP_006256897.3  male-specific lethal 3 homolog isoform X2

    7. XM_006256839.5 → XP_006256901.3  male-specific lethal 3 homolog isoform X4

    8. XM_006256836.5 → XP_006256898.3  male-specific lethal 3 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6A9H7
      Related
      ENSRNOP00000090151.1, ENSRNOT00000113748.2

    9. XM_063280077.1 → XP_063136147.1  male-specific lethal 3 homolog isoform X7

    10. XM_039099827.2 → XP_038955755.1  male-specific lethal 3 homolog isoform X5

      Conserved Domains (2) summary
      pfam05712
      Location:161 → 510
      MRG
      cl28914
      Location:29 → 76
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    11. XM_039099828.2 → XP_038955756.1  male-specific lethal 3 homolog isoform X6

      Conserved Domains (2) summary
      pfam05712
      Location:160 → 509
      MRG
      cl28914
      Location:29 → 75
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    12. XM_063280080.1 → XP_063136150.1  male-specific lethal 3 homolog isoform X12

    13. XM_063280081.1 → XP_063136151.1  male-specific lethal 3 homolog isoform X13

    RNA

    1. XR_005497991.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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