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    NXF2 nuclear RNA export factor 2 [ Homo sapiens (human) ]

    Gene ID: 56001, updated on 23-Nov-2023

    Summary

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    Official Symbol
    NXF2provided by HGNC
    Official Full Name
    nuclear RNA export factor 2provided by HGNC
    Primary source
    HGNC:HGNC:8072
    See related
    Ensembl:ENSG00000269405 MIM:300315; AllianceGenome:HGNC:8072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT39; TAPL-2; TCP11X2
    Summary
    This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]
    Expression
    Restricted expression toward testis (RPKM 10.2) See more
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    Genomic context

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    See NXF2 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102247167..102326722)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100691761..100771287)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101502161..101581636)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene t-complex 11 family, X-linked 3, pseudogene Neighboring gene t-complex 11 family, X-linked 1 Neighboring gene leucine rich repeat containing 14 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20918 Neighboring gene nuclear RNA export factor 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:101726202-101726702 Neighboring gene t-complex 11 family, X-linked 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo. Zhou J, et al. Mol Med Rep, 2013 Nov. PMID 24002123
    2. De novo duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure. Chen CP, et al. Taiwan J Obstet Gynecol, 2011 Sep. PMID 22030050
    3. Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. Chen YT, et al. Hum Reprod, 2011 Dec. PMID 22016418
    4. Familial 1.1 Mb deletion in chromosome Xq22.1 associated with mental retardation and behavioural disorders in female patients. Grillo L, et al. Eur J Med Genet, 2010 Mar-Apr. PMID 20096387
    5. Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen. Dubovsky JA, et al. Clin Cancer Res, 2009 May 15. PMID 19401350

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low NXF2 expression is associated with leukemia.
      Title: The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.
    2. Data do not support role for NXF2 in male infertility.
      Title: Is there a role for the nuclear export factor 2 gene in male infertility?
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA export from nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of nuclear RNA export factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nuclear RNA export factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nuclear RNA export factor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear RNA export factor 2
    Names
    TAP-like protein 2
    cancer/testis antigen 39
    t-complex protein 11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022053.4 → NP_071336.1  nuclear RNA export factor 2

      See identical proteins and their annotated locations for NP_071336.1

      Status: REVIEWED

      Source sequence(s)
      AC234791
      Consensus CDS
      CCDS14497.1
      UniProtKB/Swiss-Prot
      Q9BXU4, Q9GZY0, Q9NSS1, Q9NX66
      Related
      ENSP00000485586.2, ENST00000625106.4
      Conserved Domains (5) summary
      smart00804
      Location:570 → 623
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:229 → 271
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:121 → 203
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:270 → 332
      LRR_8; Leucine rich repeat
      cl09109
      Location:391 → 543
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      102247167..102326722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      100691761..100771287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039910.1: Suppressed sequence

      Description
      NM_001039910.1: This RefSeq was suppressed because it is thought to represent 5' UTR rather than a distinct protein coding region.

    2. NM_017809.3: Suppressed sequence

      Description
      NM_017809.3: This RefSeq was permanently suppressed because it is now thought that this transcript does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZY0.1 GenPept UniProtKB/Swiss-Prot:Q9GZY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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