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    Mettl8 methyltransferase 8, tRNA N3-cytidine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502633, updated on 14-Sep-2024

    Summary

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    Official Symbol
    Mettl8provided by RGD
    Official Full Name
    methyltransferase 8, tRNA N3-cytidineprovided by RGD
    Primary source
    RGD:1561059
    See related
    EnsemblRapid:ENSRNOG00000009382 AllianceGenome:RGD:1561059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561059; AABR07052486.1
    Summary
    Predicted to enable histone acetyltransferase activity and mRNA methyltransferase activity. Predicted to be involved in mRNA methylation. Predicted to act upstream of or within fat cell differentiation; histone acetylation; and skeletal muscle tissue development. Predicted to be located in cytoplasm and nucleus. Orthologous to human METTL8 (methyltransferase 8, methylcytidine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 39.2), Lung (RPKM 22.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76140465..76271367, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55731453..55863652, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57257394..57642096, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486287 Neighboring gene ribosomal protein L15 like 2 Neighboring gene uncharacterized LOC134486104 Neighboring gene uncharacterized LOC134486103 Neighboring gene DDB1 and CUL4 associated factor 17 Neighboring gene cytochrome b reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation. Jakkaraju S, et al. Dev Cell, 2005 Jul. PMID 15992539
    2. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables mRNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA C3-cytosine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial
    Names
    mRNA N(3)-methylcytidine methyltransferase METTL8
    methyltransferase 8, methylcytidine
    methyltransferase like 8
    methyltransferase-like protein 8
    NP_001386442.1
    NP_001386443.1
    XP_008760176.1
    XP_038962292.1
    XP_038962293.1
    XP_063140473.1
    XP_063140474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399513.1 → NP_001386442.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM36, A6HM37
      Related
      ENSRNOP00000067958.3, ENSRNOT00000075860.3
      Conserved Domains (1) summary
      pfam13649
      Location:190 → 293
      Methyltransf_25; Methyltransferase domain

    2. NM_001399514.1 → NP_001386443.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      76140465..76271367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284403.1 → XP_063140473.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X4

    2. XM_039106364.2 → XP_038962292.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X2

      Related
      ENSRNOP00000098991.1, ENSRNOT00000139862.1
      Conserved Domains (1) summary
      pfam13649
      Location:202 → 305
      Methyltransf_25; Methyltransferase domain

    3. XM_008761954.4 → XP_008760176.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008760176.1

      UniProtKB/TrEMBL
      A6HM36, D3ZFN6
      Related
      ENSRNOP00000055322.5, ENSRNOT00000058524.7
      Conserved Domains (2) summary
      COG0500
      Location:197 → 392
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:203 → 307
      Methyltransf_12; Methyltransferase domain

    4. XM_039106365.2 → XP_038962293.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6HM36
      Related
      ENSRNOP00000105307.1, ENSRNOT00000138988.1
      Conserved Domains (1) summary
      pfam13649
      Location:165 → 268
      Methyltransf_25; Methyltransferase domain

    5. XM_063284404.1 → XP_063140474.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A096MK97
      Related
      ENSRNOP00000111422.1, ENSRNOT00000134483.1

    RNA

    1. XR_005502190.2 RNA Sequence

    2. XR_005502191.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
    Molecular Biology Databases
    Research Materials