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    Dnah7 dynein, axonemal, heavy chain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252893, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Dnah7provided by RGD
    Official Full Name
    dynein, axonemal, heavy chain 7provided by RGD
    Primary source
    RGD:621798
    See related
    EnsemblRapid:ENSRNOG00000060984 AllianceGenome:RGD:621798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    axo b
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Predicted to be located in cilium and cytosol. Predicted to be part of inner dynein arm. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 64.9), Lung (RPKM 39.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnah7 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (62454838..62760504, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (54960235..55266529, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (60070087..60330121, complement) , (59564253..59595347, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 2 Neighboring gene uncharacterized LOC120094685 Neighboring gene solute carrier family 39 member 10 Neighboring gene uncharacterized LOC120094686 Neighboring gene serine/threonine kinase 17b Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia. Zhang YJ, et al. J Biol Chem, 2002 May 17. PMID 11877439
    2. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
    3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner dynein arm assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 7
    Names
    axonemal beta dynein heavy chain 7
    axonemal dynein heavy chain b
    ciliary dynein heavy chain 7
    dynein heavy chain 7, axonemal
    dynein, axonemal, heavy polypeptide 7
    dynein-like protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419550.1 → NP_001406479.1  dynein axonemal heavy chain 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6A3H4
      Related
      ENSRNOP00000085933.1, ENSRNOT00000106935.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      62454838..62760504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084571.2 → XP_038940499.1  dynein axonemal heavy chain 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4S9
      Conserved Domains (6) summary
      COG5245
      Location:933 → 3640
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:731 → 1136
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1264 → 1590
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2285 → 2547
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:2937 → 3153
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:3694 → 3994
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_039084570.2 → XP_038940498.1  dynein axonemal heavy chain 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYD0, A0A8I6A4S9
      Related
      ENSRNOP00000070606.2, ENSRNOT00000092162.3
      Conserved Domains (6) summary
      COG5245
      Location:937 → 3644
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:735 → 1140
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1268 → 1594
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2289 → 2551
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:2941 → 3157
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:3698 → 3998
      Dynein_C; Dynein heavy chain C-terminal domain

    3. XM_039084573.2 → XP_038940501.1  dynein axonemal heavy chain 7 isoform X3

      Conserved Domains (6) summary
      pfam17857
      Location:2151 → 2210
      AAA_lid_1; AAA+ lid domain
      pfam08393
      Location:756 → 1161
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1289 → 1615
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:1937 → 2117
      AAA_7; P-loop containing dynein motor region D3
      pfam17852
      Location:1781 → 1928
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      cl38936
      Location:1603 → 1746
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63170.2 GenPept UniProtKB/Swiss-Prot:Q63170

    Gene LinkOut

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    Chemical Information
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