Csrp3 cysteine and glycine-rich protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csrp3provided by MGI
Official Full Name: cysteine and glycine-rich protein 3provided by MGI
Primary source: MGI:MGI:1330824
See related: Ensembl:ENSMUSG00000030470 AllianceGenome:MGI:1330824
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MLP; CRP3; MMLP
Summary: Enables actinin binding activity and telethonin binding activity. A structural constituent of muscle. Involved in several processes, including cardiac muscle contraction; cardiac myofibril assembly; and detection of muscle stretch. Acts upstream of or within several processes, including T-tubule organization; insulin receptor signaling pathway; and muscle cell cellular homeostasis. Located in Z disc. Is expressed in several structures, including genitourinary system; great vessel of heart; heart; limb segment; and skeletal musculature. Used to study congestive heart failure; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward heart adult (RPKM 191.8) See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 31.11 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (48480146..48497799, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (48830398..48848051, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration.
Title: Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration.
our cellular experiments suggest that protein depletion and proteasomal overload also play a role in other HCM-causing CSPR3 mutations that we investigated, indicating that reduced levels of functional MLP may be a common mechanism for HCM-causing CSPR3 mutations.
Title: Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion.
we identify a novel role for Csrp3 expression in skeletal muscle in the development of obesity-induced insulin resistance
Title: Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle.
Ablation of MLP protein (and MYBPC3) protected mice from developing the dilated cardiomyopathy phenotype.
Title: Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy.
Cardiac overexpression of muscle LIM protein does not modulate the heart's response to various forms of pathological stress.
Title: Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP).
Loss of MLP leads to dilated cardiomyopathy and hearts of surviving MLP knockout mice show transient changes of intracellular calcium handling.
Title: Hearts of surviving MLP-KO mice show transient changes of intracellular calcium handling.
Report a common MLP (muscle LIM protein) variant associated with a hypertrophic cardiomyopathy and heart failure phenotype, and skeletal muscle pathology.
Title: A common MLP (muscle LIM protein) variant is associated with cardiomyopathy.
MLP binds directly to CFL2 in human cardiac and skeletal muscles.
Title: Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.
Mice with knockout of muscle-LIM protein exhibit prolongation of atrial and ventricular conduction and an increased ventricular vulnerability.
Title: Reduced delayed rectifier K+ current, altered electrophysiology, and increased ventricular vulnerability in MLP-deficient mice.
Reduced MLP-calcineurin signaling predisposes to adverse remodeling after myocardial infarct.
Title: Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csrp3 (e-PCR), detects polymorphism
- UniSTS:508565

Csrp3 (e-PCR), detects polymorphism
- UniSTS:525214

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MRF binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actinin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables telethonin binding	IPI Inferred from Physical Interaction more info	PubMed
enables telethonin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-tubule organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of muscle stretch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of muscle stretch	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of actin filament severing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C/protein kinase C signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament severing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of the force of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteine and glycine-rich protein 3

Names: LIM domain protein, cardiac; cardiac LIM protein; cysteine-rich protein 3; muscle LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198841.1 → NP_001185770.1 cysteine and glycine-rich protein 3

See identical proteins and their annotated locations for NP_001185770.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC061131, BG793105, BY067937

Consensus CDS

CCDS21305.1

UniProtKB/Swiss-Prot

P50462

UniProtKB/TrEMBL

Q545C7

Related

ENSMUSP00000032658.7, ENSMUST00000032658.14

Conserved Domains (2) summary

cd09481
Location:9 → 62

LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

cd09482
Location:120 → 173

LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
NM_013808.4 → NP_038836.1 cysteine and glycine-rich protein 3

See identical proteins and their annotated locations for NP_038836.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AI314553, BC061131

Consensus CDS

CCDS21305.1

UniProtKB/Swiss-Prot

P50462

UniProtKB/TrEMBL

Q545C7

Related

ENSMUSP00000129378.3, ENSMUST00000167786.4

Conserved Domains (2) summary

cd09481
Location:9 → 62

LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

cd09482
Location:120 → 173

LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)