RGS17 regulator of G protein signaling 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS17provided by HGNC
Official Full Name: regulator of G protein signaling 17provided by HGNC
Primary source: HGNC:HGNC:14088
See related: Ensembl:ENSG00000091844 MIM:607191; AllianceGenome:HGNC:14088
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RGSZ2; RGS-17; hRGS17
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (153004459..153131282, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (154205757..154333435, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (153325594..153452417, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells.
Title: Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells.
MiR-203 inhibits cell proliferation, invasion, and migration of ovarian cancer through regulating RGS17.
Title: MiR-203 inhibits cell proliferation, invasion, and migration of ovarian cancer through regulating RGS17.
MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17.
Title: MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17.
these findings suggest that Ca(2+) positively regulates RGS17, which may represent a general mechanism by which increased Ca(2+) concentration promotes the GAP activity of the RZ subfamily, leading to RZ-mediated inhibition of Ca(2+) signaling.
Title: High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members.
Knock-down of Long non-coding RNA Linc00483 inhibited the development of cervical cancer by regulating miR-508-3p/RGS17 axis.
Title: Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical cancer by regulating miR-508-3p/RGS17 axis.
A screen of over 60,000 small molecules led to the identification of five hit compounds that inhibit the RGS17-Galphao protein-protein interaction.
Title: Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures.
data suggest that RGS17 is overexpressed in colorectal carcinoma and promotes cell proliferation, migration, and invasion
Title: G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.
Results showed that RGS17 overexpression promoted hepatocarcinoma (HCC) cell proliferation, migration, and invasion, and reversed the miR-199 mediated inhibition of proliferation, migration, and invasion.
Title: MicroRNA-199 suppresses cell proliferation, migration and invasion by downregulating RGS17 in hepatocellular carcinoma.
Taken together, the results suggested that expression of miR-203 inhibited non-small-cell lung cancer tumor growth and metastasis by targeting RGS17
Title: miR-203 inhibits cell proliferation, invasion, and migration of non-small-cell lung cancer by downregulating RGS17.
Variation in RGS17 was associated with risk for substance dependence diagnoses in both African American and European American populations.
Title: Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RGS17_3211.2 (e-PCR)
- UniSTS:466416

SHGC-78907 (e-PCR)
- UniSTS:100854

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of G-protein signaling 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012419.5 → NP_036551.3 regulator of G-protein signaling 17

See identical proteins and their annotated locations for NP_036551.3

Status: REVIEWED

Source sequence(s)

AA902430, AF202257, AL080276, AL356963, BC013117, CK902282

Consensus CDS

CCDS5244.1

UniProtKB/Swiss-Prot

Q5TF49, Q8TD61, Q9UGC6, Q9UJS8

Related

ENSP00000206262.1, ENST00000206262.2

Conserved Domains (1) summary

cl02565
Location:41 → 197

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

153004459..153131282 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418634.1 → XP_047274590.1 regulator of G-protein signaling 17 isoform X1
XM_047418636.1 → XP_047274592.1 regulator of G-protein signaling 17 isoform X3

UniProtKB/Swiss-Prot

Q5TF49, Q8TD61, Q9UGC6, Q9UJS8
XM_047418635.1 → XP_047274591.1 regulator of G-protein signaling 17 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

154205757..154333435 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355154.1 → XP_054211129.1 regulator of G-protein signaling 17 isoform X1
XM_054355156.1 → XP_054211131.1 regulator of G-protein signaling 17 isoform X3

UniProtKB/Swiss-Prot

Q5TF49, Q8TD61, Q9UGC6, Q9UJS8
XM_054355155.1 → XP_054211130.1 regulator of G-protein signaling 17 isoform X2