Trio triple functional domain (PTPRF interacting) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trioprovided by MGI
Official Full Name: triple functional domain (PTPRF interacting)provided by MGI
Primary source: MGI:MGI:1927230
See related: Ensembl:ENSMUSG00000022263 AllianceGenome:MGI:1927230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Solo; 6720464I07Rik
Summary: Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of fat cell differentiation. Predicted to be located in cell projection and early endosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone. Predicted to be extrinsic component of membrane. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 17.6), CNS E18 (RPKM 15.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B1; 15 10.4 cM

Exon count:: 62

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (27730735..28025954, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (27730649..28025848, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.
Title: Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.
distinct roles of Trio GEF domains in neurite outgrowth
Title: Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons.
Cdh2 signaling via Trio assembles adherens junctions to restrict endothelial permeability.
Title: N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.
To study the underlying mechanism, we investigated the p38 MAPK pathway and found that loss of Trio blocked the cascade transduction of p38 MAPK signaling. In conclusion, we identified Trio as a novel coordinator in regulating root development and clarified its relevant molecular events.
Title: The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway.
Trio induces RhoA activation downstream of Slit2, and support a functional role in ensuring the proper positioning of both guidepost cells and a major axonal tract.
Title: Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring.
Genetic damage to both TGEF domains altered TRIO catalytic activity, decreasing TGEF1 activity and increasing TGEF2 activity.
Title: Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.
The Trio gene regulates the neuronal development of the hippocampus and that it affects the intelligence of adult mice.
Title: Trio gene is required for mouse learning ability.
Trio may serve as a a signal integrator decoding extrinsic signals to Rho GTPases for cytoskeleton organization
Title: Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum.
findings establish Trio as a guanine nucleotide exchange factor that mediates netrin-1 signaling in axon outgrowth and guidance through its ability to activate Rac1
Title: Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.
the results show a link between Trio activity,Rac1 activation,neuronal organization,and recruitment of Cadherin-11 receptor to form a complex with Trio in hindbrain embryology.
Title: Trio controls the mature organization of neuronal clusters in the hindbrain.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124754 (e-PCR)
- UniSTS:161576

D15Mit45 (e-PCR), detects polymorphism
- UniSTS:127663

NoName (e-PCR)
- UniSTS:237274

Trio (e-PCR), detects polymorphism
- UniSTS:498414

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: triple functional domain protein

NP_001074771.1

EC 2.7.11.1

XP_006520113.1

EC 2.7.11.1

XP_006520114.1

EC 2.7.11.1

XP_006520115.1

EC 2.7.11.1

XP_006520116.1

EC 2.7.11.1

XP_006520117.1

EC 2.7.11.1

XP_030104327.1

EC 2.7.11.1

XP_036015215.1

EC 2.7.11.1

XP_036015216.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081302.1 → NP_001074771.1 triple functional domain protein

Status: VALIDATED

Source sequence(s)

AB106872, BC051169, BC060724, BY727751, CF539743

Consensus CDS

CCDS49587.1

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Related

ENSMUSP00000087714.6, ENSMUST00000090247.7

Conserved Domains (14) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1659 → 1718

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2559 → 2617

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2800 → 3054

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:69 → 204

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1970 → 2143

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:567 → 783

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2689 → 2780

I-set; Immunoglobulin I-set domain

cd13240
Location:1472 → 1594

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2148 → 2286

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2792 → 3054

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam00169
Location:2175 → 2271

PH; PH domain

pfam16609
Location:1715 → 1972

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl11960
Location:2703 → 2780

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

27730735..28025954 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520051.5 → XP_006520114.1 triple functional domain protein isoform X2

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (11) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1659 → 1718

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2559 → 2617

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:69 → 204

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1970 → 2143

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:567 → 783

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1472 → 1594

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2148 → 2286

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2788 → 3050

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam07679
Location:2685 → 2776

I-set; Immunoglobulin I-set domain

pfam16609
Location:1716 → 1963

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036159323.1 → XP_036015216.1 triple functional domain protein isoform X7

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (12) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1659 → 1718

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2559 → 2617

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:69 → 204

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1970 → 2143

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:567 → 783

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1472 → 1594

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2148 → 2286

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam07679
Location:2689 → 2780

I-set; Immunoglobulin I-set domain

pfam16609
Location:1715 → 1972

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2697 → 2700

Ig; Ig strand A' [structural motif]

cl21453
Location:2792 → 2875

PKc_like; Protein Kinases, catalytic domain
XM_006520053.5 → XP_006520116.1 triple functional domain protein isoform X5

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (11) summary

smart00150
Location:1104 → 1204

SPEC; Spectrin repeats

cd11852
Location:1620 → 1679

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2520 → 2578

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:30 → 165

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1931 → 2104

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:528 → 744

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1433 → 1555

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2247

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2753 → 3015

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam07679
Location:2650 → 2741

I-set; Immunoglobulin I-set domain

pfam16609
Location:1677 → 1924

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_036159322.1 → XP_036015215.1 triple functional domain protein isoform X4

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (12) summary

smart00150
Location:1111 → 1211

SPEC; Spectrin repeats

cd11852
Location:1627 → 1686

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2527 → 2585

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:37 → 172

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1938 → 2111

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:535 → 751

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1440 → 1562

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2116 → 2254

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2760 → 3022

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam07679
Location:2657 → 2748

I-set; Immunoglobulin I-set domain

pfam16609
Location:1683 → 1940

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2665 → 2668

Ig; Ig strand A' [structural motif]
XM_030248467.1 → XP_030104327.1 triple functional domain protein isoform X6

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (11) summary

smart00150
Location:1084 → 1184

SPEC; Spectrin repeats

cd11852
Location:1600 → 1659

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2500 → 2558

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:10 → 145

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1911 → 2084

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:508 → 724

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1413 → 1535

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2089 → 2227

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2733 → 2995

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam07679
Location:2630 → 2721

I-set; Immunoglobulin I-set domain

pfam16609
Location:1657 → 1904

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006520052.4 → XP_006520115.1 triple functional domain protein isoform X3

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (11) summary

smart00150
Location:1118 → 1218

SPEC; Spectrin repeats

cd11852
Location:1634 → 1693

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2534 → 2592

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:44 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1945 → 2118

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:542 → 758

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1447 → 1569

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2123 → 2261

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2767 → 3029

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam07679
Location:2664 → 2755

I-set; Immunoglobulin I-set domain

pfam16609
Location:1691 → 1938

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006520050.5 → XP_006520113.1 triple functional domain protein isoform X1

UniProtKB/Swiss-Prot

Q0KL02, Q3U522, Q6P9K6, Q80W23

Conserved Domains (11) summary

smart00150
Location:1142 → 1242

SPEC; Spectrin repeats

cd11852
Location:1658 → 1717

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2558 → 2616

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:68 → 203

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1969 → 2142

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:566 → 782

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1471 → 1593

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2147 → 2285

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14113
Location:2791 → 3053

STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

pfam07679
Location:2688 → 2779

I-set; Immunoglobulin I-set domain

pfam16609
Location:1715 → 1962

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_006520054.5 → XP_006520117.1 triple functional domain protein isoform X8

UniProtKB/TrEMBL

A0A2I3BRP6

Related

ENSMUSP00000154653.2, ENSMUST00000227337.2

Conserved Domains (7) summary

smart00150
Location:1143 → 1243

SPEC; Spectrin repeats

cd11852
Location:1659 → 1718

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:69 → 204

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1295 → 1465

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:567 → 783

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1472 → 1594

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

pfam16609
Location:1716 → 1889

SH3-RhoG_link; SH3-RhoGEF linking unstructured region