CDK12 cyclin dependent kinase 12 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDK12provided by HGNC
Official Full Name: cyclin dependent kinase 12provided by HGNC
Primary source: HGNC:HGNC:24224
See related: Ensembl:ENSG00000167258 MIM:615514; AllianceGenome:HGNC:24224
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRK7; CRKR; CRKRS
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in several processes, including positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. Biomarker of gastric adenocarcinoma; hepatocellular carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (39461486..39567559)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (40325392..40431128)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (37617739..37690797)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of CDK12 with NXF1 is a new node for the linking mechanism between transcription and transportation of mRNA.
Title: Interaction of CDK12 with NXF1 is a new node for the linking mechanism between transcription and transportation of mRNA.
CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma.
Title: CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma.
Structure-independent machine-learning predictions of the CDK12 interactome.
Title: Structure-independent machine-learning predictions of the CDK12 interactome.
Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects.
Title: Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects.
Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer.
Title: Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer.
Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease.
Title: Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease.
ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.
Title: ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.
Trans-Regulation of Alternative PD-L1 mRNA Processing by CDK12 in Non-Small-Cell Lung Cancer Cells.
Title: Trans-Regulation of Alternative PD-L1 mRNA Processing by CDK12 in Non-Small-Cell Lung Cancer Cells.
Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.
Title: Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.
CDK12 Promotes the Proliferation, Migration, and Angiogenesis of Gastric Carcinoma via Activating the PI3K/AKT/mTOR Signaling Pathway.
Title: CDK12 Promotes the Proliferation, Migration, and Angiogenesis of Gastric Carcinoma via Activating the PI3K/AKT/mTOR Signaling Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-58832 (e-PCR)
- UniSTS:94464

RH92543 (e-PCR)
- UniSTS:91185

L18221 (e-PCR)
- UniSTS:55120

RH45437 (e-PCR)
- UniSTS:20580

CRK7_9758 (e-PCR)
- UniSTS:468358

RH70045 (e-PCR)
- UniSTS:69043

RH102939 (e-PCR)
- UniSTS:97273

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin K-CDK12 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 12

Names: CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12

NP_055898.1

EC 2.7.11.22

EC 2.7.11.23

NP_057591.2

EC 2.7.11.22

EC 2.7.11.23

XP_005257513.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523195.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523196.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523197.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523199.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523200.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523208.1

EC 2.7.11.22

EC 2.7.11.23

XP_011523209.1

EC 2.7.11.22

EC 2.7.11.23

XP_016880242.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292209.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292211.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292212.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292213.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292214.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292215.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292216.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292217.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292218.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292219.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292220.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292221.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292222.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292223.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292224.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292225.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292226.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292228.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292229.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292230.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292231.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292232.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292233.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292234.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292235.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292236.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292237.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292238.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292239.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292240.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292241.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292242.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292243.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292244.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292245.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292246.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292247.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292248.1

EC 2.7.11.22

EC 2.7.11.23

XP_047292249.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172424.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172425.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172426.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172427.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172428.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172429.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172430.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172431.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172432.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172433.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172434.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172435.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172436.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172437.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172438.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172439.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172440.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172441.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172442.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172443.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172444.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172445.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172446.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172447.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172448.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172449.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172450.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172451.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172452.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172453.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172454.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172455.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172456.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172457.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172458.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172459.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172460.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172461.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172462.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172463.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172464.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172465.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172466.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172467.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172468.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172469.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172470.1

EC 2.7.11.22

EC 2.7.11.23

XP_054172471.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_065324.1 RefSeqGene

Range

5001..78059

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1413

mRNA and Protein(s)

NM_015083.4 → NP_055898.1 cyclin-dependent kinase 12 isoform 2

See identical proteins and their annotated locations for NP_055898.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC009283, AK302645, BC150265, BE003756, BM557102

Consensus CDS

CCDS45666.1

UniProtKB/TrEMBL

J3QSD7

Related

ENSP00000407720.2, ENST00000430627.6

Conserved Domains (2) summary

smart00220
Location:727 → 1020

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_016507.4 → NP_057591.2 cyclin-dependent kinase 12 isoform 1

See identical proteins and their annotated locations for NP_057591.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.

Source sequence(s)

AC009283, AF227198, AK302645, BC150265, BE003756, BM557102

Consensus CDS

CCDS11337.1

UniProtKB/Swiss-Prot

A7E2B2, B4DYX4, B9EIQ6, O94978, Q9NYV4

UniProtKB/TrEMBL

J3QSD7

Related

ENSP00000398880.4, ENST00000447079.6

Conserved Domains (2) summary

smart00220
Location:727 → 1020

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

39461486..39567559

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436256.1 → XP_047292212.1 cyclin-dependent kinase 12 isoform X3
XM_047436261.1 → XP_047292217.1 cyclin-dependent kinase 12 isoform X3
XM_047436260.1 → XP_047292216.1 cyclin-dependent kinase 12 isoform X3
XM_011524897.3 → XP_011523199.1 cyclin-dependent kinase 12 isoform X3

See identical proteins and their annotated locations for XP_011523199.1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (1) summary

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_047436255.1 → XP_047292211.1 cyclin-dependent kinase 12 isoform X3
XM_011524895.3 → XP_011523197.1 cyclin-dependent kinase 12 isoform X3

See identical proteins and their annotated locations for XP_011523197.1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (1) summary

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_011524893.3 → XP_011523195.1 cyclin-dependent kinase 12 isoform X3

See identical proteins and their annotated locations for XP_011523195.1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (1) summary

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_011524894.3 → XP_011523196.1 cyclin-dependent kinase 12 isoform X3

See identical proteins and their annotated locations for XP_011523196.1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (1) summary

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_047436258.1 → XP_047292214.1 cyclin-dependent kinase 12 isoform X3
XM_011524906.3 → XP_011523208.1 cyclin-dependent kinase 12 isoform X3

See identical proteins and their annotated locations for XP_011523208.1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (1) summary

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_047436259.1 → XP_047292215.1 cyclin-dependent kinase 12 isoform X3
XM_011524898.3 → XP_011523200.1 cyclin-dependent kinase 12 isoform X3

See identical proteins and their annotated locations for XP_011523200.1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (1) summary

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_047436257.1 → XP_047292213.1 cyclin-dependent kinase 12 isoform X3
XM_047436278.1 → XP_047292234.1 cyclin-dependent kinase 12 isoform X5
XM_047436267.1 → XP_047292223.1 cyclin-dependent kinase 12 isoform X5
XM_047436277.1 → XP_047292233.1 cyclin-dependent kinase 12 isoform X5
XM_047436268.1 → XP_047292224.1 cyclin-dependent kinase 12 isoform X5
XM_047436265.1 → XP_047292221.1 cyclin-dependent kinase 12 isoform X5
XM_047436266.1 → XP_047292222.1 cyclin-dependent kinase 12 isoform X5
XM_047436270.1 → XP_047292226.1 cyclin-dependent kinase 12 isoform X5
XM_047436273.1 → XP_047292229.1 cyclin-dependent kinase 12 isoform X5
XM_047436275.1 → XP_047292231.1 cyclin-dependent kinase 12 isoform X5
XM_047436276.1 → XP_047292232.1 cyclin-dependent kinase 12 isoform X5
XM_047436274.1 → XP_047292230.1 cyclin-dependent kinase 12 isoform X5
XM_047436279.1 → XP_047292235.1 cyclin-dependent kinase 12 isoform X5
XM_047436269.1 → XP_047292225.1 cyclin-dependent kinase 12 isoform X5
XM_047436272.1 → XP_047292228.1 cyclin-dependent kinase 12 isoform X5
XM_011524907.3 → XP_011523209.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2, J3QSD7

Related

ENSP00000453329.2, ENST00000559663.2

Conserved Domains (2) summary

smart00220
Location:727 → 1020

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:719 → 1020

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_047436287.1 → XP_047292243.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_047436288.1 → XP_047292244.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_047436289.1 → XP_047292245.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_047436293.1 → XP_047292249.1 cyclin-dependent kinase 12 isoform X9
XM_047436262.1 → XP_047292218.1 cyclin-dependent kinase 12 isoform X4
XM_047436264.1 → XP_047292220.1 cyclin-dependent kinase 12 isoform X4
XM_047436263.1 → XP_047292219.1 cyclin-dependent kinase 12 isoform X4
XM_047436282.1 → XP_047292238.1 cyclin-dependent kinase 12 isoform X6
XM_047436283.1 → XP_047292239.1 cyclin-dependent kinase 12 isoform X6
XM_047436280.1 → XP_047292236.1 cyclin-dependent kinase 12 isoform X6
XM_047436281.1 → XP_047292237.1 cyclin-dependent kinase 12 isoform X6
XM_047436284.1 → XP_047292240.1 cyclin-dependent kinase 12 isoform X6
XM_047436285.1 → XP_047292241.1 cyclin-dependent kinase 12 isoform X6
XM_047436286.1 → XP_047292242.1 cyclin-dependent kinase 12 isoform X6
XM_047436290.1 → XP_047292246.1 cyclin-dependent kinase 12 isoform X8
XM_017024753.3 → XP_016880242.1 cyclin-dependent kinase 12 isoform X8

UniProtKB/TrEMBL

J3QSD7
XM_047436292.1 → XP_047292248.1 cyclin-dependent kinase 12 isoform X8
XM_047436291.1 → XP_047292247.1 cyclin-dependent kinase 12 isoform X8

Related

ENSP00000464641.1, ENST00000584632.5
XM_005257456.5 → XP_005257513.1 cyclin-dependent kinase 12 isoform X1

UniProtKB/TrEMBL

J3QSD7

Conserved Domains (2) summary

smart00220
Location:726 → 1019

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:718 → 1019

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_047436253.1 → XP_047292209.1 cyclin-dependent kinase 12 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

40325392..40431128

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316455.1 → XP_054172430.1 cyclin-dependent kinase 12 isoform X3
XM_054316463.1 → XP_054172438.1 cyclin-dependent kinase 12 isoform X3
XM_054316462.1 → XP_054172437.1 cyclin-dependent kinase 12 isoform X3
XM_054316454.1 → XP_054172429.1 cyclin-dependent kinase 12 isoform X3
XM_054316453.1 → XP_054172428.1 cyclin-dependent kinase 12 isoform X3
XM_054316458.1 → XP_054172433.1 cyclin-dependent kinase 12 isoform X3
XM_054316451.1 → XP_054172426.1 cyclin-dependent kinase 12 isoform X3
XM_054316452.1 → XP_054172427.1 cyclin-dependent kinase 12 isoform X3
XM_054316459.1 → XP_054172434.1 cyclin-dependent kinase 12 isoform X3
XM_054316457.1 → XP_054172432.1 cyclin-dependent kinase 12 isoform X3
XM_054316460.1 → XP_054172435.1 cyclin-dependent kinase 12 isoform X3
XM_054316461.1 → XP_054172436.1 cyclin-dependent kinase 12 isoform X3
XM_054316456.1 → XP_054172431.1 cyclin-dependent kinase 12 isoform X3
XM_054316479.1 → XP_054172454.1 cyclin-dependent kinase 12 isoform X5
XM_054316469.1 → XP_054172444.1 cyclin-dependent kinase 12 isoform X5
XM_054316478.1 → XP_054172453.1 cyclin-dependent kinase 12 isoform X5
XM_054316470.1 → XP_054172445.1 cyclin-dependent kinase 12 isoform X5
XM_054316467.1 → XP_054172442.1 cyclin-dependent kinase 12 isoform X5
XM_054316468.1 → XP_054172443.1 cyclin-dependent kinase 12 isoform X5
XM_054316472.1 → XP_054172447.1 cyclin-dependent kinase 12 isoform X5
XM_054316474.1 → XP_054172449.1 cyclin-dependent kinase 12 isoform X5
XM_054316476.1 → XP_054172451.1 cyclin-dependent kinase 12 isoform X5
XM_054316477.1 → XP_054172452.1 cyclin-dependent kinase 12 isoform X5
XM_054316475.1 → XP_054172450.1 cyclin-dependent kinase 12 isoform X5
XM_054316480.1 → XP_054172455.1 cyclin-dependent kinase 12 isoform X5
XM_054316471.1 → XP_054172446.1 cyclin-dependent kinase 12 isoform X5
XM_054316473.1 → XP_054172448.1 cyclin-dependent kinase 12 isoform X5
XM_054316489.1 → XP_054172464.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_054316488.1 → XP_054172463.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_054316490.1 → XP_054172465.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_054316491.1 → XP_054172466.1 cyclin-dependent kinase 12 isoform X7

UniProtKB/TrEMBL

H0YLT2
XM_054316496.1 → XP_054172471.1 cyclin-dependent kinase 12 isoform X9
XM_054316464.1 → XP_054172439.1 cyclin-dependent kinase 12 isoform X4
XM_054316466.1 → XP_054172441.1 cyclin-dependent kinase 12 isoform X4
XM_054316465.1 → XP_054172440.1 cyclin-dependent kinase 12 isoform X4
XM_054316483.1 → XP_054172458.1 cyclin-dependent kinase 12 isoform X6
XM_054316484.1 → XP_054172459.1 cyclin-dependent kinase 12 isoform X6
XM_054316481.1 → XP_054172456.1 cyclin-dependent kinase 12 isoform X6
XM_054316482.1 → XP_054172457.1 cyclin-dependent kinase 12 isoform X6
XM_054316485.1 → XP_054172460.1 cyclin-dependent kinase 12 isoform X6
XM_054316486.1 → XP_054172461.1 cyclin-dependent kinase 12 isoform X6
XM_054316487.1 → XP_054172462.1 cyclin-dependent kinase 12 isoform X6
XM_054316492.1 → XP_054172467.1 cyclin-dependent kinase 12 isoform X8
XM_054316493.1 → XP_054172468.1 cyclin-dependent kinase 12 isoform X8
XM_054316495.1 → XP_054172470.1 cyclin-dependent kinase 12 isoform X8
XM_054316494.1 → XP_054172469.1 cyclin-dependent kinase 12 isoform X8
XM_054316449.1 → XP_054172424.1 cyclin-dependent kinase 12 isoform X1
XM_054316450.1 → XP_054172425.1 cyclin-dependent kinase 12 isoform X2