NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029615.1 RefSeqGene
- Range
-
5321..29290
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001164.5 → NP_001155.1 amyloid beta precursor protein binding family B member 1 isoform a
See identical proteins and their annotated locations for NP_001155.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as E9). This isoform is exclusively expressed in neurons.
- Source sequence(s)
-
BC010854, HY145957, L77864
- Consensus CDS
-
CCDS66018.1
- UniProtKB/Swiss-Prot
- A1E379, A6NH82, A6NL69, B7Z1J5, B7Z1J6, B7Z2Y0, D3DQT2, O00213, Q7Z324, Q96A93, V9GYK0, V9GYT4
- UniProtKB/TrEMBL
-
A0A075B7G8
- Related
- ENSP00000477213.1, ENST00000609360.6
- Conserved Domains (3) summary
-
- cd01271
Location:535 → 660
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:368 → 507
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:255 → 283
- WW; WW domain
-
NM_001257319.3 → NP_001244248.1 amyloid beta precursor protein binding family B member 1 isoform g
See identical proteins and their annotated locations for NP_001244248.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (g) with a shorter and distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
BX538185, DC316489
- Consensus CDS
-
CCDS66017.1
- UniProtKB/TrEMBL
- B7Z327, B7Z9K0
- Related
- ENSP00000476846.1, ENST00000608655.6
- Conserved Domains (3) summary
-
- cd01271
Location:315 → 440
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:148 → 287
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:35 → 63
- WW; WW domain
-
NM_001257320.2 → NP_001244249.1 amyloid beta precursor protein binding family B member 1 isoform d
See identical proteins and their annotated locations for NP_001244249.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (d) with a shorter N-terminus, compared to isoform 1. Variants 4, 5, and 6 all encode the same isoform (d).
- Source sequence(s)
-
BM145723, EF103274, HY118301
- Consensus CDS
-
CCDS66015.1
- UniProtKB/TrEMBL
- B7Z327, B7Z9K0
- Related
- ENSP00000476871.1, ENST00000608704.5
- Conserved Domains (3) summary
-
- cd01271
Location:276 → 401
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:109 → 248
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:5 → 24
- WW; WW domain
-
NM_001257321.2 → NP_001244250.1 amyloid beta precursor protein binding family B member 1 isoform d
See identical proteins and their annotated locations for NP_001244250.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (d) with a shorter N-terminus, compared to isoform 1. Variants 4, 5, and 6 all encode the same isoform (d).
- Source sequence(s)
-
AK297550, BM145723, EF103274
- Consensus CDS
-
CCDS66015.1
- UniProtKB/TrEMBL
- B7Z327, B7Z9K0
- Related
- ENSP00000476442.1, ENST00000608394.5
- Conserved Domains (3) summary
-
- cd01271
Location:276 → 401
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:109 → 248
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:5 → 24
- WW; WW domain
-
NM_001257323.3 → NP_001244252.1 amyloid beta precursor protein binding family B member 1 isoform f
See identical proteins and their annotated locations for NP_001244252.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region, and lacks an alternate, in-frame exon in the coding region compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (f) that is shorter with a distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
AK295241, BC010854, DC316489
- Consensus CDS
-
CCDS58114.1
- UniProtKB/TrEMBL
- B7Z327, B7Z9K0
- Related
- ENSP00000433338.1, ENST00000530885.5
- Conserved Domains (3) summary
-
- cd01271
Location:313 → 438
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:148 → 285
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:35 → 63
- WW; WW domain
-
NM_001257325.3 → NP_001244254.1 amyloid beta precursor protein binding family B member 1 isoform e
See identical proteins and their annotated locations for NP_001244254.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (e) with a shorter and distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
AK293554, BC010854, DC306210, DC319935
- Consensus CDS
-
CCDS66016.1
- UniProtKB/TrEMBL
- B7Z327, B7Z9K0
- Related
- ENSP00000477069.1, ENST00000609331.5
- Conserved Domains (3) summary
-
- cd01271
Location:300 → 425
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:133 → 272
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:20 → 48
- WW; WW domain
-
NM_001257326.2 → NP_001244255.1 amyloid beta precursor protein binding family B member 1 isoform d
See identical proteins and their annotated locations for NP_001244255.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (d) with a shorter N-terminus, compared to isoform 1. Variants 4, 5, and 6 all encode the same isoform (d).
- Source sequence(s)
-
AK293550, AK297550, BC010854, BM145723
- Consensus CDS
-
CCDS66015.1
- UniProtKB/TrEMBL
- B7Z327, B7Z9K0
- Related
- ENSP00000476646.1, ENST00000608645.5
- Conserved Domains (3) summary
-
- cd01271
Location:276 → 401
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:109 → 248
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:5 → 24
- WW; WW domain
-
NM_145689.3 → NP_663722.1 amyloid beta precursor protein binding family B member 1 isoform b
See identical proteins and their annotated locations for NP_663722.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate, in-frame exon in the coding region compared to variant 1. This results in a protein that maintains the reading frame but is a shorter isoform (b, also known as delta E9), compared to isoform a. This encoded isoform (b) is widely expressed in all non-neuronal cells but is not expressed in differentiated neurons.
- Source sequence(s)
-
BC010854, HY138432
- Consensus CDS
-
CCDS31410.1
- UniProtKB/TrEMBL
-
A0A075B7G8
- Related
- ENSP00000311912.3, ENST00000311051.7
- Conserved Domains (3) summary
-
- cd01271
Location:533 → 658
- PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
- cd01272
Location:368 → 505
- PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
- pfam00397
Location:255 → 283
- WW; WW domain
RNA
-
NR_047512.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (11) uses an alternate acceptor splice site in the 3' terminal exon compared to variant 1. The resulting open reading frame (ORF) has no stop codon, and no other ORF is supported. Therefore, this is likely to be a non-coding transcript and subject to degradation via the nonstop-mediated mRNA surveillance pathway.
- Source sequence(s)
-
AF394214, BC010854, BM145723, HY145957
- Related
-
ENST00000608435.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000011.10 Reference GRCh38.p14 Primary Assembly
- Range
-
6395124..6419453 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060935.1 Alternate T2T-CHM13v2.0
- Range
-
6453583..6477913 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001257322.1: Suppressed sequence
- Description
- NM_001257322.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
-
NM_001257324.1: Suppressed sequence
- Description
- NM_001257324.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.