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    MT1HL1 metallothionein 1H like 1 [ Homo sapiens (human) ]

    Gene ID: 645745, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MT1HL1provided by HGNC
    Official Full Name
    metallothionein 1H like 1provided by HGNC
    Primary source
    HGNC:HGNC:31864
    See related
    Ensembl:ENSG00000244020 AllianceGenome:HGNC:31864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT1P2
    Summary
    This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013]
    Orthologs
    all
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    Genomic context

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    See MT1HL1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (237004103..237004441, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (236415116..236415454, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (237167403..237167741, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904563 Neighboring gene uncharacterized LOC107985368 Neighboring gene VISTA enhancer hs2137 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:237173080-237174075 Neighboring gene VISTA enhancer hs2138 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:237179824-237180353 Neighboring gene MPRA-validated peak789 silencer Neighboring gene ribosomal protein L35 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:237238747-237239412 Neighboring gene ryanodine receptor 2 Neighboring gene RN7SK pseudogene 195 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:237451188-237452387 Neighboring gene microRNA 4428

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detoxification of copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metallothionein 1H-like protein 1
    Names
    MT-1H-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276687.2 → NP_001263616.1  metallothionein 1H-like protein 1

      See identical proteins and their annotated locations for NP_001263616.1

      Status: VALIDATED

      Source sequence(s)
      AF333388, AL359259
      Consensus CDS
      CCDS31068.1
      UniProtKB/Swiss-Prot
      P0DM35
      Related
      ENSP00000476141.1, ENST00000464121.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      237004103..237004441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      236415116..236415454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_007037.2: Suppressed sequence

      Description
      NG_007037.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein and is not a pseudogene.

    2. NM_001039954.2: Suppressed sequence

      Description
      NM_001039954.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DM35.1 GenPept UniProtKB/Swiss-Prot:P0DM35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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