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    SPOPL speckle type BTB/POZ protein like [ Homo sapiens (human) ]

    Gene ID: 339745, updated on 28-Oct-2024

    Summary

    Official Symbol
    SPOPLprovided by HGNC
    Official Full Name
    speckle type BTB/POZ protein likeprovided by HGNC
    Primary source
    HGNC:HGNC:27934
    See related
    Ensembl:ENSG00000144228 AllianceGenome:HGNC:27934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTBD33
    Summary
    Enables identical protein binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in appendix (RPKM 7.5), lymph node (RPKM 7.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPOPL in Genome Data Viewer
    Location:
    2q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (138501770..138573547)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (138947462..139019229)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (139259340..139331117)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF14 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11986 Neighboring gene SPOPL divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16595 Neighboring gene uncharacterized LOC124905958 Neighboring gene long intergenic non-protein coding RNA 2631

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ53775

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    speckle-type POZ protein-like
    Names
    HIB homolog 2
    roadkill homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001664.3NP_001001664.1  speckle-type POZ protein-like

      See identical proteins and their annotated locations for NP_001001664.1

      Status: VALIDATED

      Source sequence(s)
      AC092620, AC114763
      Consensus CDS
      CCDS33298.1
      UniProtKB/Swiss-Prot
      Q6IQ16
      Related
      ENSP00000280098.4, ENST00000280098.9
      Conserved Domains (3) summary
      cd18343
      Location:179301
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:297392
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28166
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      138501770..138573547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444116.1XP_047300072.1  speckle-type POZ protein-like isoform X1

    2. XM_047444115.1XP_047300071.1  speckle-type POZ protein-like isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      138947462..139019229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341698.1XP_054197673.1  speckle-type POZ protein-like isoform X1

    2. XM_054341697.1XP_054197672.1  speckle-type POZ protein-like isoform X1