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    HISLA HIF1A stabilizing long noncoding RNA [ Homo sapiens (human) ]

    Gene ID: 283587, updated on 10-Oct-2023

    Summary

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    Official Symbol
    HISLAprovided by HGNC
    Official Full Name
    HIF1A stabilizing long noncoding RNAprovided by HGNC
    Primary source
    HGNC:HGNC:49467
    See related
    Ensembl:ENSG00000258867 AllianceGenome:HGNC:49467
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC01146
    Expression
    Biased expression in liver (RPKM 4.5) and prostate (RPKM 1.5) See more
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    Genomic context

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    See HISLA in Genome Data Viewer
    Location:
    14q31.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88024550..88087346)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82245178..82307975)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88490894..88553690)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8834 Neighboring gene RNA, U6 small nuclear 835, pseudogene Neighboring gene long intergenic non-protein coding RNA 1147 Neighboring gene NANOG hESC enhancer GRCh37_chr14:88503612-88504113 Neighboring gene G protein-coupled receptor 65 Neighboring gene uncharacterized LOC107984699 Neighboring gene uncharacterized LOC105370612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8835 Neighboring gene potassium two pore domain channel subfamily K member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo. Ma X, et al. J Transl Med, 2022 Jan 31. PMID 35101062, Free PMC Article
    2. Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Chen F, et al. Nat Cell Biol, 2019 Apr. PMID 30936474
    3. Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens. Rubicz R, et al. Genet Epidemiol, 2014 Jul. PMID 24962563, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo.
      Title: Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • HIF-1alpha-stabilizing long noncoding RNA
    • long intergenic non-protein coding RNA 1146

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_046094.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL157955, BC029479
      Related
      ENST00000556033.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      88024550..88087346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      82245178..82307975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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