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    Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114513, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Rasgrf2provided by RGD
    Official Full Name
    RAS protein-specific guanine nucleotide-releasing factor 2provided by RGD
    Primary source
    RGD:69413
    See related
    Ensembl:ENSRNOG00000056151 AllianceGenome:RGD:69413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in response to endoplasmic reticulum stress. Predicted to act upstream of or within long-term synaptic potentiation and regulation of NMDA receptor activity. Predicted to be located in endoplasmic reticulum. Orthologous to human RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 85.6), Brain (RPKM 75.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasgrf2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (24848699..25096773, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (23113613..23361537, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (21460041..21698937, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100551 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene mutS homolog 3 Neighboring gene dihydrofolate reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo. Zhang GC, et al. Neurosci Lett, 2007 Nov 5. PMID 17931779
    2. Analysis of candidate genes included in the mammary cancer susceptibility 1 (Mcs1) region. Laes JF, et al. Mamm Genome, 2001 Mar. PMID 11252168
    3. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Fan WT, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707409
    4. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Arozarena I, et al. Mol Cell Biol, 2004 Feb. PMID 14749369, Free PMC Article
    5. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. Tian X, et al. EMBO J, 2004 Apr 7. PMID 15029245, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data identify the Ras activator, Ras-GRF1, although not Ras-GRF2, as a susceptible target to cocaine stimulation in striatal neurons
      Title: Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo.
    2. RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex
      Title: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-specific guanine nucleotide-releasing factor 2
    Names
    guanine nucleotide-releasing factor 2
    ras guanine nucleotide exchange factor 2
    ras-GRF2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053721.3 → NP_446173.2  ras-specific guanine nucleotide-releasing factor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q99JE4
      UniProtKB/TrEMBL
      A0A8I6AL55
      Related
      ENSRNOP00000096121.1, ENSRNOT00000096916.1
      Conserved Domains (5) summary
      smart00147
      Location:950 → 1186
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00233
      Location:480 → 588
      PH; Pleckstrin homology domain
      smart00325
      Location:247 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13261
      Location:19 → 158
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      cl02520
      Location:852 → 924
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      24848699..25096773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101563.2 → XP_038957491.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q99JE4
      Conserved Domains (6) summary
      smart00147
      Location:935 → 1171
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00325
      Location:247 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13261
      Location:19 → 158
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:480 → 587
      PH; PH domain
      pfam00618
      Location:623 → 671
      RasGEF_N; RasGEF N-terminal motif
      cl02520
      Location:837 → 909
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    2. XM_063281151.1 → XP_063137221.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

      UniProtKB/Swiss-Prot
      Q99JE4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JE4.1 GenPept UniProtKB/Swiss-Prot:Q99JE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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