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    Chek2 checkpoint kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114212, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Chek2provided by RGD
    Official Full Name
    checkpoint kinase 2provided by RGD
    Primary source
    RGD:621543
    See related
    EnsemblRapid:ENSRNOG00000037509 AllianceGenome:RGD:621543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Chk2; Rad53
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and regulation of cell cycle phase transition. Predicted to be located in Golgi apparatus; PML body; and chromosome, telomeric region. Predicted to be active in cytoplasm and nucleus. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 60.6), Spleen (RPKM 55.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chek2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51448838..51481159, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45788823..45821382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51845574..51878098, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC102553561 Neighboring gene uncharacterized LOC120096015 Neighboring gene HscB mitochondrial iron-sulfur cluster co-chaperone Neighboring gene unc-51 like autophagy activating kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells. Xin F, et al. Mutat Res Genet Toxicol Environ Mutagen, 2014 Jul 15. PMID 25344109
    2. The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity. Krueger SA, et al. Int J Radiat Oncol Biol Phys, 2010 Aug 1. PMID 20637979, Free PMC Article
    3. Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. Ou TT, et al. J Ethnopharmacol, 2011 Apr 26. PMID 21396995
    4. Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells. Yoo BH, et al. Int J Cancer, 2012 Jul 15. PMID 21834075
    5. Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days: relationship between cell cycle aberration and carcinogenesis. Taniai E, et al. Arch Toxicol, 2012 Sep. PMID 22411272

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chk-2 is an important novel component of anoikis-promoting machinery of intestinal epithelial cells
      Title: Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells.
    2. Data demonstrate that polyamines regulate c-Myc translation in IECs through HuR phosphorylation by Chk2 and provide new insight into the molecular functions of cellular polyamines.
      Title: Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation.
    3. an important role for the DNA damage response mediated by ATR-Chk2 in p53 activation and renal cell apoptosis during cisplatin nephrotoxicity.
      Title: ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to bisphenol A IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glycoside IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Chk2
    Names
    CHK2 checkpoint homolog
    protein kinase Chk2
    NP_446129.1
    XP_006249580.1
    XP_006249581.1
    XP_006249582.1
    XP_006249583.1
    XP_063127056.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053677.1 → NP_446129.1  serine/threonine-protein kinase Chk2

      See identical proteins and their annotated locations for NP_446129.1

      Status: PROVISIONAL

      Source sequence(s)
      AF134054
      UniProtKB/TrEMBL
      A0A0G2K8L3, A6J285, F7F4E2, Q9R019
      Related
      ENSRNOP00000053643.3, ENSRNOT00000056800.3
      Conserved Domains (2) summary
      cd00060
      Location:96 → 204
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:216 → 489
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      51448838..51481159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249519.4 → XP_006249581.1  serine/threonine-protein kinase Chk2 isoform X1

      See identical proteins and their annotated locations for XP_006249581.1

      UniProtKB/TrEMBL
      A0A0G2K8L3, A6J285, F7F4E2, Q9R019
      Conserved Domains (2) summary
      cd00060
      Location:96 → 204
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:216 → 489
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_006249521.5 → XP_006249583.1  serine/threonine-protein kinase Chk2 isoform X1

      See identical proteins and their annotated locations for XP_006249583.1

      UniProtKB/TrEMBL
      A0A0G2K8L3, A6J285, F7F4E2, Q9R019
      Conserved Domains (2) summary
      cd00060
      Location:96 → 204
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:216 → 489
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_006249518.5 → XP_006249580.1  serine/threonine-protein kinase Chk2 isoform X1

      See identical proteins and their annotated locations for XP_006249580.1

      UniProtKB/TrEMBL
      A0A0G2K8L3, A6J285, F7F4E2, Q9R019
      Conserved Domains (2) summary
      cd00060
      Location:96 → 204
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:216 → 489
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_006249520.5 → XP_006249582.1  serine/threonine-protein kinase Chk2 isoform X1

      See identical proteins and their annotated locations for XP_006249582.1

      UniProtKB/TrEMBL
      A0A0G2K8L3, A6J285, F7F4E2, Q9R019
      Conserved Domains (2) summary
      cd00060
      Location:96 → 204
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:216 → 489
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_063270986.1 → XP_063127056.1  serine/threonine-protein kinase Chk2 isoform X2

      Related
      ENSRNOP00000109711.1, ENSRNOT00000163168.1
    Nucleotide Protein Strain
    Heading Accession and Version

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