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    Sppl2b signal peptide peptidase-like 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362828, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sppl2bprovided by RGD
    Official Full Name
    signal peptide peptidase-like 2Bprovided by RGD
    Primary source
    RGD:1308556
    See related
    EnsemblRapid:ENSRNOG00000057881 AllianceGenome:RGD:1308556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308556
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 60.0), Kidney (RPKM 58.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sppl2b in Genome Data Viewer
    Location:
    7q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9494593..9507317, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8843918..8856642, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11712187..11724915, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene transmembrane serine protease 9 Neighboring gene uncharacterized LOC120093773 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene leucine rich repeat and Ig domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). Fluhrer R, et al. J Biol Chem, 2012 Feb 10. PMID 22194595, Free PMC Article
    2. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Fluhrer R, et al. Nat Cell Biol, 2006 Aug. PMID 16829951
    3. In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy. Petroff OA, et al. J Neurochem, 1990 Apr. PMID 2313285
    4. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. Martin L, et al. J Biol Chem, 2009 Feb 27. PMID 19114711
    5. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. Nyborg AC, et al. FASEB J, 2006 Aug. PMID 16873890

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables aspartic endopeptidase activity, intramembrane cleaving ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal peptide peptidase-like 2B
    Names
    SPP-like 2B
    presenilin-like protein 1
    protein SPP-like 2B
    protein SPPL2b
    NP_001014222.1
    NP_001388002.1
    NP_001388003.1
    XP_006241010.1
    XP_008763332.2
    XP_008763333.1
    XP_008763334.1
    XP_038935313.1
    XP_038935314.1
    XP_038935317.1
    XP_063119791.1
    XP_063119793.1
    XP_063119794.1
    XP_063119795.1
    XP_063119796.1
    XP_063119797.1
    XP_063119798.1
    XP_063119800.1
    XP_063119801.1
    XP_063119802.1
    XP_063119803.1
    XP_063119804.1
    XP_063119805.1
    XP_063119806.1
    XP_063119807.1
    XP_063119809.1
    XP_063119810.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014200.2 → NP_001014222.1  signal peptide peptidase-like 2B isoform 2 precursor

      See identical proteins and their annotated locations for NP_001014222.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5PQL3
      UniProtKB/TrEMBL
      A0A8I5ZVS2
      Related
      ENSRNOP00000081849.1, ENSRNOT00000109298.2
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
      pfam04258
      Location:206 → 498
      Peptidase_A22B; Signal peptide peptidase

    2. NM_001401073.1 → NP_001388002.1  signal peptide peptidase-like 2B isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8E3
      Related
      ENSRNOP00000074120.3, ENSRNOT00000084144.3

    3. NM_001401074.1 → NP_001388003.1  signal peptide peptidase-like 2B isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9494593..9507317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263736.1 → XP_063119806.1  signal peptide peptidase-like 2B isoform X19

    2. XM_063263734.1 → XP_063119804.1  signal peptide peptidase-like 2B isoform X17

    3. XM_063263735.1 → XP_063119805.1  signal peptide peptidase-like 2B isoform X18

    4. XM_006240948.3 → XP_006241010.1  signal peptide peptidase-like 2B isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZVS2, A0A8L2R960
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
      pfam04258
      Location:206 → 498
      Peptidase_A22B; Signal peptide peptidase

    5. XM_063263732.1 → XP_063119802.1  signal peptide peptidase-like 2B isoform X13

    6. XM_063263726.1 → XP_063119796.1  signal peptide peptidase-like 2B isoform X5

    7. XM_008765112.3 → XP_008763334.1  signal peptide peptidase-like 2B isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZVS2
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
      pfam04258
      Location:206 → 551
      Peptidase_A22B; Signal peptide peptidase

    8. XM_063263723.1 → XP_063119793.1  signal peptide peptidase-like 2B isoform X2

    9. XM_039079386.1 → XP_038935314.1  signal peptide peptidase-like 2B isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZVS2
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 474
      Peptidase_A22B; Signal peptide peptidase

    10. XM_063263727.1 → XP_063119797.1  signal peptide peptidase-like 2B isoform X6

    11. XM_063263733.1 → XP_063119803.1  signal peptide peptidase-like 2B isoform X16

    12. XM_063263725.1 → XP_063119795.1  signal peptide peptidase-like 2B isoform X4

    13. XM_063263724.1 → XP_063119794.1  signal peptide peptidase-like 2B isoform X3

    14. XM_008765110.3 → XP_008763332.2  signal peptide peptidase-like 2B isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZVS2

    15. XM_008765111.3 → XP_008763333.1  signal peptide peptidase-like 2B isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZVS2
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
      pfam04258
      Location:207 → 552
      Peptidase_A22B; Signal peptide peptidase

    16. XM_063263728.1 → XP_063119798.1  signal peptide peptidase-like 2B isoform X10

    17. XM_063263721.1 → XP_063119791.1  signal peptide peptidase-like 2B isoform X1

    18. XM_063263731.1 → XP_063119801.1  signal peptide peptidase-like 2B isoform X12

    19. XM_063263730.1 → XP_063119800.1  signal peptide peptidase-like 2B isoform X12

    20. XM_063263740.1 → XP_063119810.1  signal peptide peptidase-like 2B isoform X22

    21. XM_063263737.1 → XP_063119807.1  signal peptide peptidase-like 2B isoform X20

    22. XM_063263739.1 → XP_063119809.1  signal peptide peptidase-like 2B isoform X21

    23. XM_039079385.2 → XP_038935313.1  signal peptide peptidase-like 2B isoform X14

      UniProtKB/TrEMBL
      A0A8I6GG67
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 552
      Peptidase_A22B; Signal peptide peptidase

    24. XM_039079389.2 → XP_038935317.1  signal peptide peptidase-like 2B isoform X23

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      cl01342
      Location:207 → 311
      Peptidase_A22B; Signal peptide peptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQL3.1 GenPept UniProtKB/Swiss-Prot:Q5PQL3

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