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    H4cl1 histone H4C like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102548682, updated on 29-Feb-2024

    Summary

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    Official Symbol
    H4cl1provided by RGD
    Official Full Name
    histone H4C like 1provided by RGD
    Primary source
    RGD:7725170
    See related
    AllianceGenome:RGD:7725170
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in chromatin assembly and negative regulation of megakaryocyte differentiation. Predicted to be located in nuclear chromosome. Predicted to be part of nucleosome. Orthologous to human H4C6 (H4 clustered histone 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See H4cl1 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41796600..41860389)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41368743..41426735)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43616218..43673659)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 17, member 2 Neighboring gene H1.1 linker histone, cluster member Neighboring gene tripartite motif containing 38 Neighboring gene uncharacterized LOC134482711 Neighboring gene uncharacterized LOC134482710 Neighboring gene H3 clustered histone 1 Neighboring gene histone cluster 1 H2A family member F Neighboring gene histone cluster 1 H2A family member H Neighboring gene H2B clustered histone 3 Neighboring gene PC-esterase domain containing 1A, pseudogene 1 Neighboring gene H1.2 linker histone, cluster member Neighboring gene homeostatic iron regulator Neighboring gene Histone cluster 1, H2an-like 1, pseudogene 2 Neighboring gene histone cluster 1 H2B family member Q Neighboring gene H1.6 linker histone, cluster member Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mitra P, et al. Mol Cell Biol, 2003 Nov. PMID 14585971, Free PMC Article
    2. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Sims JK, et al. Mol Cell Biol, 2008 Jul. PMID 18474616, Free PMC Article
    3. Structure of human nucleosome containing the testis-specific histone variant TSH2B. Urahama T, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699735, Free PMC Article
    4. Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis. Zhai N, et al. J Mol Cell Biol, 2012 Aug. PMID 22368283
    5. Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T. Tachiwana H, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498094, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CENP-A containing nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein H4cl1
    Names
    histone H3
    histone H4
    histone H4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      41796600..41860389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600719.3 → XP_017456208.2  uncharacterized protein H4cl1

      Conserved Domains (2) summary
      PLN00035
      Location:240 → 342
      PLN00035; histone H4; Provisional
      PTZ00018
      Location:125 → 237
      PTZ00018; histone H3; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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