U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Jsrp1 junctional sarcoplasmic reticulum protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690423, updated on 10-Jul-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Jsrp1provided by RGD
    Official Full Name
    junctional sarcoplasmic reticulum protein 1provided by RGD
    Primary source
    RGD:1596084
    See related
    EnsemblRapid:ENSRNOG00000032951 AllianceGenome:RGD:1596084
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of ryanodine-sensitive calcium-release channel activity and skeletal muscle contraction. Predicted to act upstream of or within protein localization to membrane. Predicted to be active in sarcoplasmic reticulum. Orthologous to human JSRP1 (junctional sarcoplasmic reticulum protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 1006.4) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Jsrp1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9539997..9556730)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8889486..8906055)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11769950..11774373)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene anti-Mullerian hormone Neighboring gene splicing factor 3A subunit 2 Neighboring gene pleckstrin homology domain containing J1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. Anderson AA, et al. J Cell Sci, 2006 May 15. PMID 16638807, Free PMC Article
    2. JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Yasuda T, et al. Hum Mutat, 2013 Jan. PMID 22927026, Free PMC Article
    3. The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel. Anderson AA, et al. J Biol Chem, 2003 Oct 10. PMID 12871958
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ryanodine-sensitive calcium-release channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    junctional sarcoplasmic reticulum protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109591.1 → NP_001103061.1  junctional sarcoplasmic reticulum protein 1

      See identical proteins and their annotated locations for NP_001103061.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A6K8F7, D4A2V6
      Related
      ENSRNOP00000047240.5, ENSRNOT00000044417.6
      Conserved Domains (2) summary
      PRK12678
      Location:159 → 338
      PRK12678; transcription termination factor Rho; Provisional
      pfam15312
      Location:113 → 166
      JSRP; Junctional sarcoplasmic reticulum protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9539997..9556730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079925.2 → XP_038935853.1  junctional sarcoplasmic reticulum protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K8F7, D4A2V6
      Conserved Domains (2) summary
      PRK12678
      Location:159 → 338
      PRK12678; transcription termination factor Rho; Provisional
      pfam15312
      Location:113 → 166
      JSRP; Junctional sarcoplasmic reticulum protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools