Slc31a2 solute carrier family 31 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc31a2provided by RGD
Official Full Name: solute carrier family 31 member 2provided by RGD
Primary source: RGD:1307963
See related: EnsemblRapid:ENSRNOG00000013631 AllianceGenome:RGD:1307963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable copper ion transmembrane transporter activity. Predicted to be involved in copper ion import. Predicted to act upstream of or within intracellular copper ion homeostasis and regulation of copper ion transmembrane transport. Predicted to be located in endosome; lysosomal membrane; and plasma membrane. Orthologous to human SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 165.6), Lung (RPKM 67.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (80753589..80764126)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (75738008..75748542)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (78120606..78131111)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ctr2 promotes copper uptake at the plasma membrane and plays a role in regulating copper levels in COS-7 cells
Title: Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in copper ion import	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within copper ion transmembrane transport	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in copper ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of copper ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein SLC31A2

Names: probable low affinity copper uptake protein 2; solute carrier family 31 (copper transporter), member 2; solute carrier family 31 (copper transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033693.2 → NP_001028865.2 protein SLC31A2

See identical proteins and their annotated locations for NP_001028865.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6A3L3, A6J7T6, D4AAE7

Related

ENSRNOP00000019379.5, ENSRNOT00000019379.9

Conserved Domains (1) summary

pfam04145
Location:3 → 135

Ctr; Ctr copper transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

80753589..80764126

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109465.2 → XP_038965393.1 protein SLC31A2 isoform X1

UniProtKB/TrEMBL

A0A8I6A3L3

Conserved Domains (1) summary

pfam04145
Location:15 → 110

Ctr; Ctr copper transporter family