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    Tpm1 tropomyosin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24851, updated on 2-Nov-2024

    Summary

    Official Symbol
    Tpm1provided by RGD
    Official Full Name
    tropomyosin 1provided by RGD
    Primary source
    RGD:3898
    See related
    EnsemblRapid:ENSRNOG00000018184 AllianceGenome:RGD:3898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tma2; Tmsa; Alpha-tm
    Summary
    This gene is a member of the tropomyosin family and encodes a protein that heterodimerizes with a beta subunit, binding actin in both muscle and nonmuscle cells. In both smooth and striated muscle cells, it plays a role in calcium dependent-regulation of muscle contraction. In nonmuscle cells, it stabilizes cytoskeleton actin filaments. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Muscle (RPKM 22251.9) and Heart (RPKM 10996.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tpm1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76516654..76543661, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67635479..67662330, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72814737..72841496, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480198 Neighboring gene U6 spliceosomal RNA Neighboring gene lactamase, beta Neighboring gene talin 2 Neighboring gene microRNA 190 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in muscle filament sliding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ATP-dependent activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of heart rate by epinephrine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bleb IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bleb ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tropomyosin alpha-1 chain
    Names
    hepatoma alpha tropomyosin
    smooth muscle alpha-tropomyosin
    striated muscle alpha-tropomyosin
    tropomyosin 1, alpha
    tropomyosin 3 alpha
    tropomyosin-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034068.1NP_001029240.1  tropomyosin alpha-1 chain isoform a

      See identical proteins and their annotated locations for NP_001029240.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AA899493, AF372217, CB787774, M60667
      UniProtKB/TrEMBL
      A0A096MIT6, Q91XN6
      Conserved Domains (1) summary
      pfam00261
      Location:48259
      Tropomyosin
    2. NM_001034069.1NP_001029241.1  tropomyosin alpha-1 chain isoform Tpm1.6cy

      See identical proteins and their annotated locations for NP_001029241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.6, also known as variant 2) contains a different 3' exon compared to variant 1. The resulting protein (isoform Tpm1.6cy, also referred to as TM-2) is shorter and has a distinct C-terminus compared to isoform a. Isoform Tpm1.6cy is the same length as isoforms Tpm1.7cy and Tpm1.3sm but is the product of alternate splicing and contains short regions of sequence differences.
      Source sequence(s)
      BC078780, BU670983, M60666
      UniProtKB/TrEMBL
      A0A8L2UK34, A6KEY3
      Related
      ENSRNOP00000070151.3, ENSRNOT00000085894.3
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    3. NM_001034070.1NP_001029242.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

      See identical proteins and their annotated locations for NP_001029242.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.7, also known as variant 3) has multiple differences in the coding region, compared to variant 1, resulting in a shorter protein (isoform Tpm1.7cy, also referred to as TM-3). Isoform Tpm1.7cy is the same length as isoforms Tpm1.6cy and Tpm1.3sm but is the product of alternate splicing and contains short regions of sequence differences.
      Source sequence(s)
      BC078780, CB787774, CK483405, M60667
      UniProtKB/TrEMBL
      Q63583, Q63607
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    4. NM_001034071.1NP_001029243.1  tropomyosin alpha-1 chain isoform Tpm1.3sm

      See identical proteins and their annotated locations for NP_001029243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.3, also known as variant 4) has multiple differences in the coding region, compared to variant 1, resulting in a shorter protein (isoform Tpm1.3sm). Isoform Tpm1.3sm is the same length as isoforms Tpm1.6cy and Tpm1.7cy but is the product of alternate splicing and contains short regions of sequence differences.
      Source sequence(s)
      AF372216, BC078780, BU670983, M60667
      UniProtKB/TrEMBL
      F7FK40, Q923Z2
      Conserved Domains (2) summary
      PHA03248
      Location:51147
      PHA03248; DNA packaging tegument protein UL25; Provisional
      pfam00261
      Location:48282
      Tropomyosin; Tropomyosin
    5. NM_001034072.1NP_001029244.1  tropomyosin alpha-1 chain isoform Tpm1.10br

      See identical proteins and their annotated locations for NP_001029244.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.10, also known as variant 5) contains a different 3' exon compared to variant 1. The resulting protein (isoform Tpm1.10br, also referred to as TMBr-1) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF372217, BE118215, CB787774, M34135
      UniProtKB/TrEMBL
      A6KEY5
      Related
      ENSRNOP00000024575.7, ENSRNOT00000024575.10
      Conserved Domains (1) summary
      pfam00261
      Location:48280
      Tropomyosin
    6. NM_001034073.1NP_001029245.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

      See identical proteins and their annotated locations for NP_001029245.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.8, also known as variant 7) has multiple differences in the coding region compared to variant 1. These differences result in an isoform (Tpm1.8cy, also referred to as TM-5a) that is shorter and has distinct N- and C-termini compared to isoform a. Isoform Tpm1.8cy is the same length as isoforms Tpm1.9cy and Tpm1.13 but is the product of alternate splicing and contains short regions of sequence differences.
      Source sequence(s)
      BC078780, CB585296, M60668
      UniProtKB/TrEMBL
      A6KEZ2
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    7. NM_001034074.1NP_001029246.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

      See identical proteins and their annotated locations for NP_001029246.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.9, also known as variant 8) has multiple differences in the coding region, compared to variant 1. These differences result in an isoform (Tpm1.9cy, also referred to as TM-5b) that is shorter and has distinct N- and C-termini compared to isoform a. Isoform Tpm1.9cy is the same length as isoforms Tpm1.8cy and Tpm1.13 but is the product of alternate splicing and contains short regions of sequence differences.
      Source sequence(s)
      BC078780, CO562261, M34136
      UniProtKB/TrEMBL
      A0A0G2JSQ4, A0A9K3Y6T5, Q6AZ25
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    8. NM_001034075.1NP_001029247.1  tropomyosin alpha-1 chain isoform Tpm1.13

      See identical proteins and their annotated locations for NP_001029247.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.13, also known as variant 9) has multiple differences in the coding region, compared to variant 1. These differences result in an isoform (Tpm1.13) that is shorter and has distinct N- and C- termini compared to isoform a. Isoform Tpm1.13 is the same length as isoforms Tpm1.8cy and Tpm1.9cy but is the product of alternate splicing and contains short regions of sequence differences.
      Source sequence(s)
      AA899493, AF372215, CO562261, X02412
      UniProtKB/TrEMBL
      A6KEZ6, Q91XN7
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    9. NM_001301336.1NP_001288265.1  tropomyosin alpha-1 chain isoform Tpm1.1st

      See identical proteins and their annotated locations for NP_001288265.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.1st, also known as variant 10) contains a alternate 3' exon compared to variant 1. The resulting protein (isoform Tpm1.1st) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P04692, P06469, P18342, P18343, P18344, Q53X09, Q63582, Q63608, Q63609
      UniProtKB/TrEMBL
      A0A0G2K7F7, A6KEY9
      Related
      ENSRNOP00000048499.3, ENSRNOT00000048044.7
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    10. NM_001301342.1NP_001288271.1  tropomyosin alpha-1 chain isoform Tpm1.2st

      See identical proteins and their annotated locations for NP_001288271.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.2, also known as variant 11) has multiple differences in the coding region, compared to variant 1, resulting in a shorter protein (isoform Tpm1.2st). The resulting protein (isoform Tpm1.2st) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI603512, CF108680, FQ074026, FQ217616
      UniProtKB/TrEMBL
      A0A8I6A156, A6KEY7
      Conserved Domains (3) summary
      PHA03248
      Location:51147
      PHA03248; DNA packaging tegument protein UL25; Provisional
      pfam00261
      Location:48282
      Tropomyosin; Tropomyosin
      pfam07851
      Location:180274
      TMPIT; TMPIT-like protein
    11. NM_001301736.1NP_001288665.1  tropomyosin alpha-1 chain isoform Tpm1.12br

      See identical proteins and their annotated locations for NP_001288665.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.12, also known as variant 12) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 1, resulting in a shorter protein (isoform Tpm1.12br). The resulting protein (isoform Tpm1.12br) is shorter than isoform a.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KEZ3
      Conserved Domains (1) summary
      pfam00261
      Location:12244
      Tropomyosin
    12. NM_019131.2NP_062004.1  tropomyosin alpha-1 chain isoform Tpm1.11br

      See identical proteins and their annotated locations for NP_062004.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.11, also known as variant 6) has a different 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform Tpm1.11br, also referred to as TMBr-2) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AA899493, BC078780, CO562261, M34134
      UniProtKB/TrEMBL
      A6KEZ5
      Conserved Domains (1) summary
      pfam00261
      Location:12223
      Tropomyosin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76516654..76543661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264927.1XP_063120997.1  tropomyosin alpha-1 chain isoform X6

    2. XM_006243390.5XP_006243452.1  tropomyosin alpha-1 chain isoform X2

      See identical proteins and their annotated locations for XP_006243452.1

      UniProtKB/TrEMBL
      A6KEY1
      Related
      ENSRNOP00000024617.7, ENSRNOT00000024617.9
      Conserved Domains (3) summary
      PHA03248
      Location:51147
      PHA03248; DNA packaging tegument protein UL25; Provisional
      pfam00261
      Location:48282
      Tropomyosin; Tropomyosin
      pfam07851
      Location:180264
      TMPIT; TMPIT-like protein
    3. XM_063264926.1XP_063120996.1  tropomyosin alpha-1 chain isoform X5

      UniProtKB/TrEMBL
      A6KEY4
    4. XM_063264928.1XP_063120998.1  tropomyosin alpha-1 chain isoform X7

      UniProtKB/TrEMBL
      A0A8J8YA57
    5. XM_063264930.1XP_063121000.1  tropomyosin alpha-1 chain isoform X11

      UniProtKB/TrEMBL
      F7FIS4
      Related
      ENSRNOP00000054446.5, ENSRNOT00000057641.7
    6. XM_006243395.5XP_006243457.1  tropomyosin alpha-1 chain isoform X10

      See identical proteins and their annotated locations for XP_006243457.1

      Conserved Domains (1) summary
      pfam00261
      Location:12244
      Tropomyosin
    7. XM_063264935.1XP_063121005.1  tropomyosin alpha-1 chain isoform X16

      UniProtKB/TrEMBL
      A6KEZ4
    8. XM_063264933.1XP_063121003.1  tropomyosin alpha-1 chain isoform X14

    9. XM_008766207.4XP_008764429.1  tropomyosin alpha-1 chain isoform X1

      See identical proteins and their annotated locations for XP_008764429.1

      UniProtKB/TrEMBL
      A6KEY8
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    10. XM_063264934.1XP_063121004.1  tropomyosin alpha-1 chain isoform X15

      Related
      ENSRNOP00000024493.6, ENSRNOT00000024493.9
    11. XM_063264924.1XP_063120994.1  tropomyosin alpha-1 chain isoform X3

    12. XM_063264929.1XP_063120999.1  tropomyosin alpha-1 chain isoform X8

    13. XM_063264932.1XP_063121002.1  tropomyosin alpha-1 chain isoform X13

    14. XM_006243393.4XP_006243455.1  tropomyosin alpha-1 chain isoform X9

      See identical proteins and their annotated locations for XP_006243455.1

      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    15. XM_063264925.1XP_063120995.1  tropomyosin alpha-1 chain isoform X4

    16. XM_063264931.1XP_063121001.1  tropomyosin alpha-1 chain isoform X12