Ap3b1 adaptor related protein complex 3 subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ap3b1provided by RGD
Official Full Name: adaptor related protein complex 3 subunit beta 1provided by RGD
Primary source: RGD:1310256
See related: EnsemblRapid:ENSRNOG00000010624 AllianceGenome:RGD:1310256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP-dependent protein binding activity and protein phosphatase binding activity. Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle budding from endosome. Predicted to act upstream of or within with a negative effect on mRNA transcription by RNA polymerase II and regulation of catalytic activity. Predicted to act upstream of or within several processes, including animal organ development; establishment of protein localization to organelle; and vesicle organization. Predicted to be located in several cellular components, including axon cytoplasm; clathrin-coated vesicle membrane; and mitochondrion. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 169.3), Thymus (RPKM 132.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (27331241..27535683)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (25600069..25800937)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (24022815..24227522)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C78395 (e-PCR)
- UniSTS:160330

RH141388 (e-PCR)
- UniSTS:223384

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation, exogenous lipid antigen via MHC class Ib	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within granulocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet dense granule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NK T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AP-3 adaptor complex	IEA Inferred from Electronic Annotation more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvesicle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AP-3 complex subunit beta-1

Names: adaptor-related protein complex 3, beta 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429216.1 → NP_001416145.1 AP-3 complex subunit beta-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I4W7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

27331241..27535683

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281703.1 → XP_063137773.1 AP-3 complex subunit beta-1 isoform X1

Related

ENSRNOP00000110034.1, ENSRNOT00000173506.1
XM_063281704.1 → XP_063137774.1 AP-3 complex subunit beta-1 isoform X2
XM_063281705.1 → XP_063137775.1 AP-3 complex subunit beta-1 isoform X3
XM_063281706.1 → XP_063137776.1 AP-3 complex subunit beta-1 isoform X4
XM_063281707.1 → XP_063137777.1 AP-3 complex subunit beta-1 isoform X4
XM_063281708.1 → XP_063137778.1 AP-3 complex subunit beta-1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107646.1: Suppressed sequence

Description

NM_001107646.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.