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    Lmcd1 LIM and cysteine-rich domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494021, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lmcd1provided by RGD
    Official Full Name
    LIM and cysteine-rich domains 1provided by RGD
    Primary source
    RGD:1308963
    See related
    EnsemblRapid:ENSRNOG00000005690 AllianceGenome:RGD:1308963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LIMD1
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade and regulation of cardiac muscle hypertrophy. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human LMCD1 (LIM and cysteine rich domains 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 547.0), Heart (RPKM 355.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmcd1 in Genome Data Viewer
    Location:
    4q41
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (146948993..147007878)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (145393153..145452049)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (144192989..144252554)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486832 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 16 Neighboring gene ssu-2 homolog Neighboring gene caveolin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart. Luosujärvi H, et al. Blood Press, 2010 Feb. PMID 20175653
    2. Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions. Govatati S, et al. Arterioscler Thromb Vasc Biol, 2020 May. PMID 32160773, Free PMC Article
    3. LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling. Bian ZY, et al. Hypertension, 2010 Feb. PMID 20026769
    4. LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Rath N, et al. Mol Cell Biol, 2005 Oct. PMID 16199866, Free PMC Article
    5. Proteomics characterization of extracellular space components in the human aorta. Didangelos A, et al. Mol Cell Proteomics, 2010 Sep. PMID 20551380, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel p38 MAPK target dyxin may play an important role in regulating hypertrophic process.
      Title: A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    LIM and cysteine-rich domains protein 1
    Names
    dyxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008562.1 → NP_001008562.1  LIM and cysteine-rich domains protein 1

      See identical proteins and their annotated locations for NP_001008562.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079071
      UniProtKB/TrEMBL
      A6IBM6, Q6AYF2
      Related
      ENSRNOP00000007523.4, ENSRNOT00000007523.7
      Conserved Domains (3) summary
      cd09340
      Location:243 → 300
      LIM1_Testin_like; The first LIM domain of Testin-like family
      cd09829
      Location:116 → 203
      PET_testin; The PET domain of Testin
      cl02475
      Location:306 → 359
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      146948993..147007878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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