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    Asb14 ankyrin repeat and SOCS box-containing 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680076, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Asb14provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 14provided by RGD
    Primary source
    RGD:1596812
    See related
    EnsemblRapid:ENSRNOG00000013346 AllianceGenome:RGD:1596812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB14 (ankyrin repeat and SOCS box containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 151.7), Muscle (RPKM 148.3) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2102303..2131379)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2095567..2123259)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2537209..2556930)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 12 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene protein phosphatase 1, regulatory subunit 26, pseudogene 1 Neighboring gene host cell factor C1 regulator 1-like Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene HESX homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 14
    Names
    Ankyrin repeat and SOCS box-containing protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170749.1 → NP_001164220.1  ankyrin repeat and SOCS box protein 14

      See identical proteins and their annotated locations for NP_001164220.1

      Status: VALIDATED

      Source sequence(s)
      AW919055, FM122942, JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P0C927
      UniProtKB/TrEMBL
      F1M704
      Related
      ENSRNOP00000098971.1, ENSRNOT00000164434.1
      Conserved Domains (4) summary
      cd00204
      Location:119 → 243
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03730
      Location:536 → 592
      SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
      pfam12796
      Location:161 → 252
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:189 → 220
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      2102303..2131379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275710.1 → XP_063131780.1  ankyrin repeat and SOCS box protein 14 isoform X1

      Related
      ENSRNOP00000017995.5, ENSRNOT00000017995.6

    2. XM_063275711.1 → XP_063131781.1  ankyrin repeat and SOCS box protein 14 isoform X1

    3. XM_063275709.1 → XP_063131779.1  ankyrin repeat and SOCS box protein 14 isoform X1

    4. XM_063275712.1 → XP_063131782.1  ankyrin repeat and SOCS box protein 14 isoform X2

      UniProtKB/Swiss-Prot
      P0C927
      UniProtKB/TrEMBL
      F1M704

    5. XM_063275713.1 → XP_063131783.1  ankyrin repeat and SOCS box protein 14 isoform X3

    RNA

    1. XR_010058318.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C927.1 GenPept UniProtKB/Swiss-Prot:P0C927

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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