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    S100A16 S100 calcium binding protein A16 [ Homo sapiens (human) ]

    Gene ID: 140576, updated on 12-Nov-2024

    Summary

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    Official Symbol
    S100A16provided by HGNC
    Official Full Name
    S100 calcium binding protein A16provided by HGNC
    Primary source
    HGNC:HGNC:20441
    See related
    Ensembl:ENSG00000188643 MIM:617437; AllianceGenome:HGNC:20441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAG13; S100F; DT1P1A7
    Summary
    Enables calcium ion binding activity and protein homodimerization activity. Predicted to act upstream of or within response to calcium ion. Located in several cellular components, including cytosol; extracellular space; and nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in esophagus (RPKM 418.9), skin (RPKM 89.4) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See S100A16 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153606883..153613137, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152744143..152750397, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153579359..153585613, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153521261-153521822 Neighboring gene Sharpr-MPRA regulatory region 14368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153522386-153522947 Neighboring gene S100 calcium binding protein A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153536677-153537434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153537435-153538192 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:153538345-153539544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153539708-153540464 Neighboring gene S100 calcium binding protein A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153546964-153547744 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153547745-153548525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153550484-153551282 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153555559-153556483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153577506-153578461 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153580804-153582003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153588740-153589240 Neighboring gene S100 calcium binding protein A14 Neighboring gene S100 calcium binding protein A13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153599403-153600228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153601055-153601878 Neighboring gene S100 calcium binding protein A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. Sapkota D, et al. BMC Cancer, 2015 Sep 9. PMID 26353754, Free PMC Article
    2. S100A16 Regulates HeLa Cell through the Phosphatidylinositol 3 Kinase (PI3K)/AKT Signaling Pathway. Zhang H, et al. Med Sci Monit, 2020 Jan 2. PMID 31894756, Free PMC Article
    3. [S100 calcium binding protein A16 promotes fat synthesis through endoplasmic reticulum stress in HepG2 cells]. Kan JB, et al. Sheng Li Xue Bao, 2019 Apr 25. PMID 31008487
    4. S100A16 suppresses the growth and survival of leukaemia cells and correlates with relapse and relapse free survival in adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia. Zhang J, et al. Br J Haematol, 2019 Jun. PMID 30916375
    5. Brain microvascular endothelial cell exosome-mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain. Xu ZH, et al. FASEB J, 2019 Feb. PMID 30183374

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S100A16 stabilizes the ITGA3-mediated ECM-receptor interaction pathway to drive the malignant properties of lung adenocarcinoma cells via binding MOV10.
      Title: S100A16 stabilizes the ITGA3‑mediated ECM‑receptor interaction pathway to drive the malignant properties of lung adenocarcinoma cells via binding MOV10.
    2. Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
      Title: Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
    3. S100A16 is a potential target for reshaping the tumor microenvironment in the hypoxic context of liver cancer.
      Title: S100A16 is a potential target for reshaping the tumor microenvironment in the hypoxic context of liver cancer.
    4. An Update on S100A16 in Human Cancer.
      Title: An Update on S100A16 in Human Cancer.
    5. S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
      Title: S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
    6. New progress with calcium-binding protein S100A16 in digestive system disease.
      Title: New progress with calcium-binding protein S100A16 in digestive system disease.
    7. Calbindin S100A16 Promotes Renal Cell Carcinoma Progression and Angiogenesis via the VEGF/VEGFR2 Signaling Pathway.
      Title: Calbindin S100A16 Promotes Renal Cell Carcinoma Progression and Angiogenesis via the VEGF/VEGFR2 Signaling Pathway.
    8. Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation.
      Title: Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation.
    9. The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1alpha/XBP1 pathway in renal tubulointerstitial fibrosis.
      Title: The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1α/XBP1 pathway in renal tubulointerstitial fibrosis.
    10. S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways.
      Title: S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC17528

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein S100-A16
    Names
    aging-associated gene 13 protein
    aging-associated protein 13
    protein S100-F

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317007.1 → NP_001303936.1  protein S100-A16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI673616, BC010541, BQ439720, HY178745
      Consensus CDS
      CCDS1045.1
      UniProtKB/Swiss-Prot
      A8K439, D3DV52, Q5RHS6, Q96FQ6
      Related
      ENSP00000357694.1, ENST00000368705.2
      Conserved Domains (1) summary
      cd05022
      Location:6 → 99
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

    2. NM_001317008.2 → NP_001303937.1  protein S100-A16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI673616, BC010541, HY178745
      Consensus CDS
      CCDS1045.1
      UniProtKB/Swiss-Prot
      A8K439, D3DV52, Q5RHS6, Q96FQ6
      Related
      ENSP00000357693.1, ENST00000368704.5
      Conserved Domains (1) summary
      cd05022
      Location:6 → 99
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

    3. NM_080388.3 → NP_525127.1  protein S100-A16

      See identical proteins and their annotated locations for NP_525127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AI673616, BC010541, BM739127
      Consensus CDS
      CCDS1045.1
      UniProtKB/Swiss-Prot
      A8K439, D3DV52, Q5RHS6, Q96FQ6
      Related
      ENSP00000357695.3, ENST00000368706.9
      Conserved Domains (1) summary
      cd05022
      Location:6 → 99
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

    RNA

    1. NR_133645.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate first exon and an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AI673616, AW954845, BC010541

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153606883..153613137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446559.1 → XP_047302515.1  protein S100-A16 isoform X1

      UniProtKB/Swiss-Prot
      A8K439, D3DV52, Q5RHS6, Q96FQ6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152744143..152750397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334493.1 → XP_054190468.1  protein S100-A16 isoform X1

      UniProtKB/Swiss-Prot
      A8K439, D3DV52, Q5RHS6, Q96FQ6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FQ6.1 GenPept UniProtKB/Swiss-Prot:Q96FQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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