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    MYCT1 MYC target 1 [ Homo sapiens (human) ]

    Gene ID: 80177, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MYCT1provided by HGNC
    Official Full Name
    MYC target 1provided by HGNC
    Primary source
    HGNC:HGNC:23172
    See related
    Ensembl:ENSG00000120279 MIM:616805; AllianceGenome:HGNC:23172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTLC
    Summary
    Predicted to act upstream of or within hematopoietic stem cell homeostasis. Located in nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 14.8), fat (RPKM 8.8) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYCT1 in Genome Data Viewer
    Location:
    6q25.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (152697897..152747181)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (153899213..153948502)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (153019032..153049320)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:152893840-152894402 Neighboring gene Nanog homeobox pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25289 Neighboring gene uncharacterized LOC105378061 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:153042324-153043523 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 2840 Neighboring gene uncharacterized LOC124901440 Neighboring gene vasoactive intestinal peptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment. Xu J, et al. Biomed Pharmacother, 2023 Sep. PMID 37499454
    2. [Cloning and characterization of MTLC, a novel gene in 6q25]. Qiu G, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2003 Apr. PMID 12673574
    3. Expression of MTLC gene in gastric carcinoma. Qiu GB, et al. World J Gastroenterol, 2003 Oct. PMID 14562369, Free PMC Article
    4. Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1 in laryngeal squamous cell carcinoma. Yang M, et al. BMC Cancer, 2012 Jun 6. PMID 22672838, Free PMC Article
    5. Transmembrane domain is crucial to the subcellular localization and function of Myc target 1. Wu S, et al. J Cell Mol Med, 2016 Mar. PMID 26710964, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
      Title: MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
    2. MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.
      Title: MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.
    3. Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells.
      Title: Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells.
    4. MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway.
      Title: MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway.
    5. Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
      Title: Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
    6. MYCT1 may synergistically interact with MAX as a co-transcription factor or a component of MAX transcriptional complex, to transcriptionally regulate the expression of miR-181a, which, in turn, decreases NPM1 expression at post-transcriptional levels, leading to enhanced apoptosis in laryngeal cancer cells
      Title: MYCT1 represses apoptosis of laryngeal cancerous cells through the MAX/miR-181a/NPM1 pathway.
    7. miR-632 was upregulated and MYCT1 was downregulated in HCC. High miR-632 or low MYCT1 expression was shown as a predictor for poor overall survival of HCC patients. The study also found miR-632 was able to regulate HCC cell growth and invasion through targeting the expression of MYCT1.
      Title: miR-632 Functions as Oncogene in Hepatocellular Carcinoma via Targeting MYCT1.
    8. YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression.
      Title: YY1 directly suppresses MYCT1 leading to laryngeal tumorigenesis and progress.
    9. Overexpression of MYCT1, decreased cell viability under serum deprivation and increased tumour cell migration ability.
      Title: Transmembrane domain is crucial to the subcellular localization and function of Myc target 1.
    10. this study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer.
      Title: Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21269, MGC156309, MGC156310

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    myc target protein 1
    Names
    myc target in myeloid cells 1
    myc target in myeloid cells protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371624.1 → NP_001358553.1  myc target protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390960
      UniProtKB/TrEMBL
      D6Q1S4, H0YDV5
      Conserved Domains (1) summary
      pfam15179
      Location:1 → 186
      Myc_target_1; Myc target protein 1

    2. NM_001371625.1 → NP_001358554.1  myc target protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390960
      UniProtKB/TrEMBL
      D6Q1S4, H0YDV5
      Conserved Domains (1) summary
      pfam15179
      Location:1 → 186
      Myc_target_1; Myc target protein 1

    3. NM_001371626.1 → NP_001358555.1  myc target protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390960
      UniProtKB/TrEMBL
      D6Q1S4, H0YDV5
      Related
      ENSP00000434396.1, ENST00000532295.1
      Conserved Domains (1) summary
      pfam15179
      Location:1 → 186
      Myc_target_1; Myc target protein 1

    4. NM_025107.3 → NP_079383.2  myc target protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079383.2

      Status: VALIDATED

      Source sequence(s)
      AL390960
      Consensus CDS
      CCDS5239.1
      UniProtKB/Swiss-Prot
      Q8N396, Q8N699, Q8TBE8, Q9H763
      UniProtKB/TrEMBL
      H0YDV5
      Related
      ENSP00000356214.5, ENST00000367245.6
      Conserved Domains (1) summary
      pfam15179
      Location:49 → 234
      Myc_target_1; Myc target protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      152697897..152747181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007059337.1 RNA Sequence

    2. XR_007059339.1 RNA Sequence

    3. XR_007059338.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      153899213..153948502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487435.1 RNA Sequence

    2. XR_008487437.1 RNA Sequence

    3. XR_008487436.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N699.1 GenPept UniProtKB/Swiss-Prot:Q8N699

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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