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    Fcrl2 Fc receptor-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310694, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fcrl2provided by RGD
    Official Full Name
    Fc receptor-like 2provided by RGD
    Primary source
    RGD:1306885
    See related
    EnsemblRapid:ENSRNOG00000016164 AllianceGenome:RGD:1306885
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Msr2; Fcrls
    Summary
    Predicted to enable protein phosphatase binding activity; signaling adaptor activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human FCRL2 (Fc receptor like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 118.5), Brain (RPKM 81.4) and 8 other tissues See more
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    Genomic context

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    See Fcrl2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (174992226..175005177, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (172694308..172707261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (186594442..186605115, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 1 Neighboring gene uncharacterized LOC134485634 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene elongator acetyltransferase complex subunit 4, pseudogene 1 Neighboring gene Cd5 molecule-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria. Sibani S, et al. Hum Mutat, 2000. PMID 10679944
    2. Molecular cloning and characterization of SPAP1, an inhibitory receptor. Xu MJ, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162587
    3. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Polson AG, et al. Int Immunol, 2006 Sep. PMID 16849395
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like 2
    Names
    Fc receptor-like S, scavenger receptor
    macrophage scavenger receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107702.1 → NP_001101172.1  Fc receptor-like 2 precursor

      See identical proteins and their annotated locations for NP_001101172.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J602, F1M652
      Related
      ENSRNOP00000021938.6, ENSRNOT00000021938.7
      Conserved Domains (5) summary
      smart00202
      Location:402 → 502
      SR; Scavenger receptor Cys-rich
      smart00409
      Location:224 → 304
      IG; Immunoglobulin
      pfam13927
      Location:122 → 181
      Ig_3; Immunoglobulin domain
      cd00096
      Location:19 → 23
      Ig; Ig strand A [structural motif]
      cl11960
      Location:19 → 85
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      174992226..175005177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102396.2 → XP_038958324.1  Fc receptor-like 2 isoform X1

      UniProtKB/TrEMBL
      A6J602, F1M652
      Conserved Domains (5) summary
      smart00202
      Location:402 → 502
      SR; Scavenger receptor Cys-rich
      smart00409
      Location:224 → 304
      IG; Immunoglobulin
      pfam13927
      Location:122 → 181
      Ig_3; Immunoglobulin domain
      cd00096
      Location:19 → 23
      Ig; Ig strand A [structural motif]
      cl11960
      Location:19 → 85
      Ig; Immunoglobulin domain

    2. XM_039102397.2 → XP_038958325.1  Fc receptor-like 2 isoform X1

      UniProtKB/TrEMBL
      A6J602, F1M652
      Conserved Domains (5) summary
      smart00202
      Location:402 → 502
      SR; Scavenger receptor Cys-rich
      smart00409
      Location:224 → 304
      IG; Immunoglobulin
      pfam13927
      Location:122 → 181
      Ig_3; Immunoglobulin domain
      cd00096
      Location:19 → 23
      Ig; Ig strand A [structural motif]
      cl11960
      Location:19 → 85
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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