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    TLE4 TLE family member 4, transcriptional corepressor [ Homo sapiens (human) ]

    Gene ID: 7091, updated on 14-Nov-2024

    Summary

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    Official Symbol
    TLE4provided by HGNC
    Official Full Name
    TLE family member 4, transcriptional corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:11840
    See related
    Ensembl:ENSG00000106829 MIM:605132; AllianceGenome:HGNC:11840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TLE4 in Genome Data Viewer
    Location:
    9q21.31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (79571965..79726882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (91730341..91885229)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (82186880..82341797)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19968 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82115206-82115783 Neighboring gene lncRNA regulator of Akt signaling associated with HCC and RCC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:82187809-82188421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19974 Neighboring gene VISTA enhancer hs1078 Neighboring gene uncharacterized LOC124902329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82267149-82267908 Neighboring gene VISTA enhancer hs1360 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82346165-82346666 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82380198-82380813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:82449531-82450161 Neighboring gene long intergenic non-protein coding RNA 1507 Neighboring gene ankyrin repeat domain-containing protein 36B-like Neighboring gene uncharacterized LOC105376101 Neighboring gene nuclear pore associated protein 1 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. Hancock DB, et al. PLoS Genet, 2009 Aug. PMID 19714205, Free PMC Article
    2. TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway. Wang SY, et al. Oncotarget, 2016 Jan 19. PMID 26701208, Free PMC Article
    3. TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia. Shin TH, et al. Leuk Res, 2016 Sep. PMID 27486062, Free PMC Article
    4. The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling. Zhang P, et al. Biochem Biophys Res Commun, 2013 Oct 25. PMID 24099773, Free PMC Article
    5. A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. Milili M, et al. Immunology, 2002 Aug. PMID 12153506, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.
      Title: TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.
    2. Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population.
      Title: Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population.
    3. the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity
      Title: TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.
    4. the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer.
      Title: TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.
    5. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing.
      Title: The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.
    6. Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7.
      Title: The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.
    7. Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4.
      Title: SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest.
    8. Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation.
      Title: Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.
    9. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Analyses of shared genetic factors between asthma and obesity in children.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
    EBI GWAS Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 4
    Names
    B lymphocyte gene 1
    enhancer of split groucho 4
    groucho-related protein 4
    transducin like enhancer of split 4
    transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282748.2 → NP_001269677.1  transducin-like enhancer protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001269677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL353813, AL358975, AL445252
      Consensus CDS
      CCDS65069.1
      UniProtKB/Swiss-Prot
      Q04727
      Related
      ENSP00000365720.4, ENST00000376537.8
      Conserved Domains (4) summary
      COG2319
      Location:511 → 803
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:518 → 802
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:522 → 561
      7WD40; WD40 repeat [structural motif]

    2. NM_001282749.2 → NP_001269678.1  transducin-like enhancer protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001269678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AL353813, AL358975
      Consensus CDS
      CCDS65070.1
      UniProtKB/Swiss-Prot
      Q04727
      Related
      ENSP00000265284.6, ENST00000265284.10
      Conserved Domains (4) summary
      COG2319
      Location:454 → 746
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:461 → 745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:465 → 504
      7WD40; WD40 repeat [structural motif]

    3. NM_001282753.2 → NP_001269682.1  transducin-like enhancer protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001269682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
      Source sequence(s)
      AL353813, AL358975, AL445252
      Consensus CDS
      CCDS75851.1
      UniProtKB/Swiss-Prot
      Q04727
      Related
      ENSP00000365727.4, ENST00000376544.7
      Conserved Domains (3) summary
      cd00200
      Location:417 → 701
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:421 → 460
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 138
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    4. NM_001282760.2 → NP_001269689.1  transducin-like enhancer protein 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in the 5' UTR and lacks an alternate in-frame exon in the coding region which results in the use of a downstream start codon compared to variant 1. It encodes isoform 5 which has a shorter N-terminus compared the isoform 1.
      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      COG2319
      Location:364 → 650
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:365 → 649
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369 → 408
      7WD40; WD40 repeat [structural motif]

    5. NM_001351541.2 → NP_001338470.1  transducin-like enhancer protein 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:499 → 783
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:503 → 542
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 151
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    6. NM_001351542.2 → NP_001338471.1  transducin-like enhancer protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:487 → 771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:491 → 530
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 139
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    7. NM_001351543.2 → NP_001338472.1  transducin-like enhancer protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BC059405, DB284195, HY012218, HY054961
      Consensus CDS
      CCDS94424.1
      UniProtKB/TrEMBL
      A0A994J7T6
      Related
      ENSP00000516378.1, ENST00000706431.1
      Conserved Domains (3) summary
      cd00200
      Location:485 → 769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:489 → 528
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 137
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    8. NM_001351546.2 → NP_001338475.1  transducin-like enhancer protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BC059405, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:484 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 136
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    9. NM_001351547.2 → NP_001338476.1  transducin-like enhancer protein 4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, HY012218
      Conserved Domains (3) summary
      cd00200
      Location:469 → 753
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:473 → 512
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 121
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    10. NM_001351550.2 → NP_001338479.1  transducin-like enhancer protein 4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:466 → 750
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:470 → 509
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 118
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    11. NM_001351552.2 → NP_001338481.1  transducin-like enhancer protein 4 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:465 → 749
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:469 → 508
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 117
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    12. NM_001351556.2 → NP_001338485.1  transducin-like enhancer protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BC059405, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:463 → 747
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:467 → 506
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 115
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    13. NM_001351558.2 → NP_001338487.1  transducin-like enhancer protein 4 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975
      Conserved Domains (3) summary
      cd00200
      Location:462 → 746
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:466 → 505
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 103
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    14. NM_001351560.2 → NP_001338489.1  transducin-like enhancer protein 4 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BI462045, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:460 → 744
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:464 → 503
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 101
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    15. NM_001351562.2 → NP_001338491.1  transducin-like enhancer protein 4 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975
      Conserved Domains (4) summary
      cd00200
      Location:410 → 694
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:414 → 453
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl26464
      Location:239 → 316
      Atrophin-1; Atrophin-1 family

    16. NM_001351563.2 → NP_001338492.1  transducin-like enhancer protein 4 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BI462045, BU428571, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:408 → 692
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:412 → 451
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 107
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    17. NM_001351564.2 → NP_001338493.1  transducin-like enhancer protein 4 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975
      Conserved Domains (3) summary
      cd00200
      Location:392 → 676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:396 → 435
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8 → 109
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    18. NM_007005.6 → NP_008936.2  transducin-like enhancer protein 4 isoform 3

      See identical proteins and their annotated locations for NP_008936.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
      Source sequence(s)
      AL353813, AL358975, AL445252
      Consensus CDS
      CCDS43837.1
      UniProtKB/Swiss-Prot
      F8W6T6, Q04727, Q3ZCS1, Q5T1Y2, Q6PCB3, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9
      Related
      ENSP00000365735.2, ENST00000376552.8
      Conserved Domains (4) summary
      COG2319
      Location:479 → 771
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:486 → 770
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:490 → 529
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_104239.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL353813, AL358975, AL445252

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      79571965..79726882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518952.2 → XP_011517254.1  transducin-like enhancer protein 4 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:578 → 870
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:585 → 869
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:589 → 628
      7WD40; WD40 repeat [structural motif]

    2. XM_006717264.2 → XP_006717327.1  transducin-like enhancer protein 4 isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:553 → 845
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:560 → 844
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:564 → 603
      7WD40; WD40 repeat [structural motif]

    3. XM_011518958.2 → XP_011517260.1  transducin-like enhancer protein 4 isoform X8

      Conserved Domains (4) summary
      COG2319
      Location:546 → 838
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:553 → 837
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:557 → 596
      7WD40; WD40 repeat [structural motif]

    4. XM_006717268.2 → XP_006717331.1  transducin-like enhancer protein 4 isoform X13

      Conserved Domains (4) summary
      COG2319
      Location:521 → 813
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:528 → 812
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:532 → 571
      7WD40; WD40 repeat [structural motif]

    5. XM_011518967.2 → XP_011517269.1  transducin-like enhancer protein 4 isoform X20

      Conserved Domains (4) summary
      COG2319
      Location:495 → 787
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:502 → 786
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:506 → 545
      7WD40; WD40 repeat [structural motif]

    6. XM_017015074.2 → XP_016870563.1  transducin-like enhancer protein 4 isoform X24

    7. XM_011518969.2 → XP_011517271.1  transducin-like enhancer protein 4 isoform X23

      Conserved Domains (4) summary
      COG2319
      Location:477 → 769
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:484 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]

    8. XM_047423820.1 → XP_047279776.1  transducin-like enhancer protein 4 isoform X25

    9. XM_011518956.2 → XP_011517258.1  transducin-like enhancer protein 4 isoform X6

      Conserved Domains (4) summary
      COG2319
      Location:550 → 842
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:557 → 841
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:561 → 600
      7WD40; WD40 repeat [structural motif]

    10. XM_047423819.1 → XP_047279775.1  transducin-like enhancer protein 4 isoform X21

    11. XM_011518957.2 → XP_011517259.1  transducin-like enhancer protein 4 isoform X7

      Conserved Domains (4) summary
      COG2319
      Location:549 → 841
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:556 → 840
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 151
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:560 → 599
      7WD40; WD40 repeat [structural motif]

    12. XM_011518959.2 → XP_011517261.1  transducin-like enhancer protein 4 isoform X9

      Conserved Domains (4) summary
      COG2319
      Location:537 → 829
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:544 → 828
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 139
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:548 → 587
      7WD40; WD40 repeat [structural motif]

    13. XM_011518965.2 → XP_011517267.1  transducin-like enhancer protein 4 isoform X18

      Conserved Domains (4) summary
      COG2319
      Location:505 → 797
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:512 → 796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 139
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:516 → 555
      7WD40; WD40 repeat [structural motif]

    14. XM_047423823.1 → XP_047279779.1  transducin-like enhancer protein 4 isoform X28

    15. XM_011518960.2 → XP_011517262.1  transducin-like enhancer protein 4 isoform X10

      Conserved Domains (4) summary
      COG2319
      Location:536 → 828
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:543 → 827
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:547 → 586
      7WD40; WD40 repeat [structural motif]

    16. XM_011518966.2 → XP_011517268.1  transducin-like enhancer protein 4 isoform X19

      Conserved Domains (4) summary
      COG2319
      Location:504 → 796
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:511 → 795
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:515 → 554
      7WD40; WD40 repeat [structural motif]

    17. XM_017015083.2 → XP_016870572.1  transducin-like enhancer protein 4 isoform X29

    18. XM_011518963.2 → XP_011517265.1  transducin-like enhancer protein 4 isoform X16

      Conserved Domains (2) summary
      cd00200
      Location:519 → 803
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:523 → 562
      7WD40; WD40 repeat [structural motif]

    19. XM_011518964.2 → XP_011517266.1  transducin-like enhancer protein 4 isoform X17

      Conserved Domains (4) summary
      COG2319
      Location:511 → 803
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:518 → 802
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:522 → 561
      7WD40; WD40 repeat [structural motif]

    20. XM_011518955.2 → XP_011517257.1  transducin-like enhancer protein 4 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:557 → 849
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:564 → 848
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 112
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:568 → 607
      7WD40; WD40 repeat [structural motif]

    21. XM_011518961.2 → XP_011517263.1  transducin-like enhancer protein 4 isoform X14

      Conserved Domains (4) summary
      COG2319
      Location:516 → 808
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:523 → 807
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 118
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:527 → 566
      7WD40; WD40 repeat [structural motif]

    22. XM_011518962.2 → XP_011517264.1  transducin-like enhancer protein 4 isoform X15

      Conserved Domains (4) summary
      COG2319
      Location:515 → 807
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:522 → 806
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 117
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:526 → 565
      7WD40; WD40 repeat [structural motif]

    23. XM_011518968.2 → XP_011517270.1  transducin-like enhancer protein 4 isoform X22

      Conserved Domains (4) summary
      COG2319
      Location:491 → 783
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:498 → 782
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 83
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:502 → 541
      7WD40; WD40 repeat [structural motif]

    24. XM_047423821.1 → XP_047279777.1  transducin-like enhancer protein 4 isoform X26

    25. XM_011518954.2 → XP_011517256.1  transducin-like enhancer protein 4 isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:563 → 855
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:570 → 854
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8 → 118
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:574 → 613
      7WD40; WD40 repeat [structural motif]

    26. XM_017015068.2 → XP_016870557.1  transducin-like enhancer protein 4 isoform X12

    27. XM_011518970.4 → XP_011517272.1  transducin-like enhancer protein 4 isoform X30

      Conserved Domains (2) summary
      pfam03920
      Location:8 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:589 → 628
      7WD40; WD40 repeat [structural motif]

    28. XM_047423824.1 → XP_047279780.1  transducin-like enhancer protein 4 isoform X31

    29. XM_011518953.3 → XP_011517255.1  transducin-like enhancer protein 4 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:576 → 868
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:583 → 867
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:13 → 131
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:587 → 626
      7WD40; WD40 repeat [structural motif]

    30. XM_017015067.2 → XP_016870556.1  transducin-like enhancer protein 4 isoform X11

    31. XM_047423822.1 → XP_047279778.1  transducin-like enhancer protein 4 isoform X27

    32. XM_011518972.4 → XP_011517274.1  transducin-like enhancer protein 4 isoform X32

      Conserved Domains (2) summary
      cd00200
      Location:228 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:232 → 271
      7WD40; WD40 repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      91730341..91885229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363677.1 → XP_054219652.1  transducin-like enhancer protein 4 isoform X1

    2. XM_054363681.1 → XP_054219656.1  transducin-like enhancer protein 4 isoform X5

    3. XM_054363684.1 → XP_054219659.1  transducin-like enhancer protein 4 isoform X8

    4. XM_054363689.1 → XP_054219664.1  transducin-like enhancer protein 4 isoform X13

    5. XM_054363696.1 → XP_054219671.1  transducin-like enhancer protein 4 isoform X20

    6. XM_054363701.1 → XP_054219676.1  transducin-like enhancer protein 4 isoform X24

    7. XM_054363699.1 → XP_054219674.1  transducin-like enhancer protein 4 isoform X23

    8. XM_054363702.1 → XP_054219677.1  transducin-like enhancer protein 4 isoform X25

    9. XM_054363682.1 → XP_054219657.1  transducin-like enhancer protein 4 isoform X6

    10. XM_054363697.1 → XP_054219672.1  transducin-like enhancer protein 4 isoform X21

    11. XM_054363683.1 → XP_054219658.1  transducin-like enhancer protein 4 isoform X7

    12. XM_054363685.1 → XP_054219660.1  transducin-like enhancer protein 4 isoform X9

    13. XM_054363694.1 → XP_054219669.1  transducin-like enhancer protein 4 isoform X18

    14. XM_054363705.1 → XP_054219680.1  transducin-like enhancer protein 4 isoform X28

    15. XM_054363686.1 → XP_054219661.1  transducin-like enhancer protein 4 isoform X10

    16. XM_054363695.1 → XP_054219670.1  transducin-like enhancer protein 4 isoform X19

    17. XM_054363706.1 → XP_054219681.1  transducin-like enhancer protein 4 isoform X29

    18. XM_054363692.1 → XP_054219667.1  transducin-like enhancer protein 4 isoform X16

    19. XM_054363693.1 → XP_054219668.1  transducin-like enhancer protein 4 isoform X17

    20. XM_054363680.1 → XP_054219655.1  transducin-like enhancer protein 4 isoform X4

    21. XM_054363700.1 → XP_054219675.1  transducin-like enhancer protein 4 isoform X33

    22. XM_054363690.1 → XP_054219665.1  transducin-like enhancer protein 4 isoform X14

    23. XM_054363691.1 → XP_054219666.1  transducin-like enhancer protein 4 isoform X15

    24. XM_054363698.1 → XP_054219673.1  transducin-like enhancer protein 4 isoform X22

    25. XM_054363703.1 → XP_054219678.1  transducin-like enhancer protein 4 isoform X26

    26. XM_054363679.1 → XP_054219654.1  transducin-like enhancer protein 4 isoform X3

    27. XM_054363688.1 → XP_054219663.1  transducin-like enhancer protein 4 isoform X12

    28. XM_054363707.1 → XP_054219682.1  transducin-like enhancer protein 4 isoform X30

    29. XM_054363708.1 → XP_054219683.1  transducin-like enhancer protein 4 isoform X31

    30. XM_054363678.1 → XP_054219653.1  transducin-like enhancer protein 4 isoform X2

    31. XM_054363687.1 → XP_054219662.1  transducin-like enhancer protein 4 isoform X11

    32. XM_054363704.1 → XP_054219679.1  transducin-like enhancer protein 4 isoform X27

    33. XM_054363709.1 → XP_054219684.1  transducin-like enhancer protein 4 isoform X32

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04727.3 GenPept UniProtKB/Swiss-Prot:Q04727

    Gene LinkOut

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