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    Acyp2 acylphosphatase 2, muscle type [ Mus musculus (house mouse) ]

    Gene ID: 75572, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acyp2provided by MGI
    Official Full Name
    acylphosphatase 2, muscle typeprovided by MGI
    Primary source
    MGI:MGI:1922822
    See related
    Ensembl:ENSMUSG00000060923 AllianceGenome:MGI:1922822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310004B09Rik
    Summary
    Predicted to enable acylphosphatase activity and identical protein binding activity. Located in mitochondrion. Is expressed in cranial ganglion; integumental system; musculoskeletal system; and salivary gland primordium. Orthologous to human ACYP2 (acylphosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 12.3), heart adult (RPKM 11.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acyp2 in Genome Data Viewer
    Location:
    11 A4; 11 18.16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30455991..30599778, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30505992..30649608, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene stress-induced phosphoprotein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29059 Neighboring gene predicted gene, 53677 Neighboring gene ciliary microtubule inner protein 6 Neighboring gene STARR-seq mESC enhancer starr_29061 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene Pea15a pseudogene Neighboring gene RNA binding motif protein pseudogene Neighboring gene coiled-coil domain containing 47 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29063 Neighboring gene STARR-seq mESC enhancer starr_29064 Neighboring gene STARR-seq mESC enhancer starr_29065 Neighboring gene ribosomal protein L7-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29066 Neighboring gene STARR-seq mESC enhancer starr_29067 Neighboring gene predicted gene 12100

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acylphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    acylphosphatase-2
    Names
    acylphosphatase, muscle type isozyme
    acylphosphate phosphohydrolase 2
    NP_083620.1
    XP_017170305.1
    XP_036012948.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029344.4 → NP_083620.1  acylphosphatase-2

      See identical proteins and their annotated locations for NP_083620.1

      Status: VALIDATED

      Source sequence(s)
      AL732595, AL844147
      Consensus CDS
      CCDS24507.1
      UniProtKB/Swiss-Prot
      P56375, Q5SPV7, Q8BQX2
      Related
      ENSMUSP00000074195.4, ENSMUST00000074613.4
      Conserved Domains (1) summary
      pfam00708
      Location:13 → 105
      Acylphosphatase; Acylphosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      30455991..30599778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157055.1 → XP_036012948.1  acylphosphatase-2 isoform X1

      Conserved Domains (1) summary
      cl00551
      Location:17 → 76
      Acylphosphatase

    2. XM_017314816.3 → XP_017170305.1  acylphosphatase-2 isoform X1

      Conserved Domains (1) summary
      cl00551
      Location:17 → 76
      Acylphosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56375.2 GenPept UniProtKB/Swiss-Prot:P56375

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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