Gdf10 growth differentiation factor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gdf10provided by MGI
Official Full Name: growth differentiation factor 10provided by MGI
Primary source: MGI:MGI:95684
See related: Ensembl:ENSMUSG00000021943 AllianceGenome:MGI:95684
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmp3b
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein has been shown to promote neural repair after stroke and may act as a tumor suppressor. [provided by RefSeq, Jul 2016]
Expression: Broad expression in adrenal adult (RPKM 52.5), limb E14.5 (RPKM 47.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.8 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (33645544..33658471)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (33923587..33936514)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion.
Title: Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion.
BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts.
Title: BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts.
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.
Title: Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.
Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis.
Title: Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis.
GDF10-/- mice exhibit hepatic lipid accumulation, fibrosis and liver injury. GDF10 attenuates nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) activity; a transcription factor known to induce de novo lipogenesis.
Title: GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury.
The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.
Title: The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.
Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh as early as E18.5, suggesting a regulation of glial development by Shh
Title: Growth and differentiation factor 10 (Gdf10) is involved in Bergmann glial cell development under Shh regulation.
Here we show that Runx2 is highly expressed in lung cancer cells and downregulates BMP-3B. The ectopic expression of Runx2, but not DNA binding mutant Runx2, in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels.
Title: Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.
data suggest that BMP-3b is secreted from adipocytes, is involved in adipocyte differentiation, and inhibits adipogenesis as a unique complex.
Title: Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex.
Sca-1 attenuated GDF10-dependent TGF-beta signaling by disrupting the heterodimerization of TbetaRI and TbetaRII receptors.
Title: Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Markers

Gdf10 (e-PCR), detects polymorphism
- UniSTS:496652

Gdf10 (e-PCR), detects polymorphism
- UniSTS:498379

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in ovulation cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in response to kainic acid	IEA Inferred from Electronic Annotation more info
involved_in response to transforming growth factor beta	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth/differentiation factor 10

Names: bone morphogenetic protein 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145741.3 → NP_665684.2 growth/differentiation factor 10 preproprotein

See identical proteins and their annotated locations for NP_665684.2

Status: REVIEWED

Source sequence(s)

AC166828, AK042684, BC058358

Consensus CDS

CCDS26927.1

UniProtKB/Swiss-Prot

P97737, Q6PE07

UniProtKB/TrEMBL

Q53X20

Related

ENSMUSP00000128621.2, ENSMUST00000168727.3

Conserved Domains (1) summary

cd19394
Location:365 → 476

TGF_beta_GDF10; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins