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    Atad2 ATPase family, AAA domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70472, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atad2provided by MGI
    Official Full Name
    ATPase family, AAA domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917722
    See related
    Ensembl:ENSMUSG00000022360 AllianceGenome:MGI:1917722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610509G12Rik
    Summary
    Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in chromatin remodeling and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; salivary gland; and spleen. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 11.8), CNS E11.5 (RPKM 11.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atad2 in Genome Data Viewer
    Location:
    15 D1; 15 24.32 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57957440..57998516, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58094044..58135525, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22299 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene STARR-positive B cell enhancer ABC_E941 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57966689-57966916 Neighboring gene STARR-positive B cell enhancer ABC_E3140 Neighboring gene predicted gene, 23475 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene predicted gene, 22488

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway. Li N, et al. Am J Physiol Cell Physiol, 2020 Jul 1. PMID 31747529
    2. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Duan Z, et al. Prostate, 2013 Apr. PMID 23038103
    3. Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers. Caron C, et al. Oncogene, 2010 Sep 16. PMID 20581866
    4. ATAD2 controls chromatin-bound HIRA turnover. Wang T, et al. Life Sci Alliance, 2021 Dec. PMID 34580178, Free PMC Article
    5. Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma. Wu G, et al. Int J Oncol, 2014 Jul. PMID 24805933

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATAD2 controls chromatin-bound HIRA turnover.
      Title: ATAD2 controls chromatin-bound HIRA turnover.
    2. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
      Title: ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
    3. Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
      Title: Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
    4. Results found that ATAD2 is highly expressed in hepatocellular carcinoma tissues and could affect the expression of hedghog pathway.
      Title: Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma.
    5. EZH2 and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development.
      Title: Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38189

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATPase family AAA domain-containing protein 2
    NP_001391691.1
    NP_001391693.1
    NP_001391694.1
    NP_001391695.1
    NP_081711.2
    XP_036015476.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404762.1 → NP_001391691.1  ATPase family AAA domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113292

    2. NM_001404764.1 → NP_001391693.1  ATPase family AAA domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113292

    3. NM_001404765.1 → NP_001391694.1  ATPase family AAA domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113292
      UniProtKB/Swiss-Prot
      Q3UYW6, Q8CDM1
      Related
      ENSMUSP00000153936.2, ENSMUST00000228783.2

    4. NM_001404766.1 → NP_001391695.1  ATPase family AAA domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113292

    5. NM_027435.3 → NP_081711.2  ATPase family AAA domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_081711.2

      Status: VALIDATED

      Source sequence(s)
      AC113292
      Consensus CDS
      CCDS37079.1
      UniProtKB/TrEMBL
      G3X963
      Related
      ENSMUSP00000043691.4, ENSMUST00000038194.5
      Conserved Domains (3) summary
      cd05528
      Location:960 → 1070
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:438 → 579
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:443 → 577
      AAA; ATPase family associated with various cellular activities (AAA)

    RNA

    1. NR_175863.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113292

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      57957440..57998516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159583.1 → XP_036015476.1  ATPase family AAA domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      cd05528
      Location:459 → 569
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:3 → 406
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      TIGR01243
      Location:3 → 172
      CDC48; AAA family ATPase, CDC48 subfamily
      cl38936
      Location:1 → 74
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153199.1: Suppressed sequence

      Description
      NM_153199.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDM1.1 GenPept UniProtKB/Swiss-Prot:Q8CDM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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