Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Svep1provided by MGI
Official Full Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1provided by MGI
Primary source: MGI:MGI:1928849
See related: Ensembl:ENSMUSG00000028369 AllianceGenome:MGI:1928849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Polydom; 1110021D17Rik; 4833413O10Rik; D430029O09Rik
Summary: Enables chromatin binding activity and integrin binding activity involved in cell-matrix adhesion. Involved in positive regulation of platelet activation. Acts upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver sinusoid; and respiratory system. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 11.5), lung adult (RPKM 7.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 31.87 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (58042796..58206596, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (58042796..58206596, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells.
Title: Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells.
SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
Title: SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1.
Title: The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.
Functional investigation of the coronary artery disease gene SVEP1.
Title: Functional investigation of the coronary artery disease gene SVEP1.
The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway.
Title: The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway.
Polydom/Svep1 is an essential extracellular factors for lymphangiogenesis.
Title: An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation.
Polydom deposited around lymphatic vessels seems to ensure Foxc2 upregulation in lymphatic endothelial cells, possibly via the Ang-2 and Tie1/Tie2 receptor system, to regulate lymphangiogenesis.
Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.
polydom is a hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand in vivo.
Title: Polydom/SVEP1 is a ligand for integrin α9β1.
Our results show that the putative promoter of SVEP1 is hypermethylated in DA3- compared with MBA-15 cells, thus regulating SVEP1 expression levels
Title: SVEP1 promoter regulation by methylation of CpG sites.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit287 (e-PCR), detects polymorphism
- UniSTS:130078

NoName (e-PCR)
- UniSTS:234927

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding involved in cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Tie signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in epidermis development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph vessel morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymph vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tight junction organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Names: polydomain protein (Polydom)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022814.2 → NP_073725.2 sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_073725.2

Status: VALIDATED

Source sequence(s)

AL805969, AL929406

Consensus CDS

CCDS18209.1

UniProtKB/Swiss-Prot

A2AVA0, Q8C720, Q8CBT2, Q922H0, Q9CUT3, Q9ES77

Related

ENSMUSP00000045856.9, ENSMUST00000042850.9

Conserved Domains (11) summary

cd00033
Location:439 → 495

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:1689 → 1742

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

smart00179
Location:1744 → 1782

EGF_CA; Calcium-binding EGF-like domain

PHA02927
Location:2709 → 2941

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:1344 → 1380

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00152
Location:1423 → 1621

PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...

pfam00084
Location:1627 → 1684

Sushi; Sushi repeat (SCR repeat)

pfam00092
Location:85 → 259

VWA; von Willebrand factor type A domain

pfam02494
Location:560 → 642

HYR; HYR domain

pfam07699
Location:1112 → 1159

GCC2_GCC3; GCC2 and GCC3

cl03620
Location:643 → 722

DUF5011; Domain of unknown function (DUF5011)