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    PTPRM protein tyrosine phosphatase receptor type M [ Homo sapiens (human) ]

    Gene ID: 5797, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PTPRMprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Mprovided by HGNC
    Primary source
    HGNC:HGNC:9675
    See related
    Ensembl:ENSG00000173482 MIM:176888; AllianceGenome:HGNC:9675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 28.8), thyroid (RPKM 25.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTPRM in Genome Data Viewer
    Location:
    18p11.23
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (7567316..8406856)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (7730572..8570006)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (7567314..8406854)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112577592 Neighboring gene uncharacterized LOC105371976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:7577695-7578451 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:7727774-7728973 Neighboring gene NANOG hESC enhancer GRCh37_chr18:7734824-7735325 Neighboring gene uncharacterized LOC124904242 Neighboring gene NANOG hESC enhancer GRCh37_chr18:7957710-7958211 Neighboring gene Sharpr-MPRA regulatory region 1937 Neighboring gene small nucleolar RNA U3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:8045403-8046602 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8062594-8063198 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:8066484-8067132 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:8084054-8084920 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8088787-8089335 Neighboring gene uncharacterized LOC107985119 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:8141627-8142826 Neighboring gene Sharpr-MPRA regulatory region 9307 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8187471-8187972 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:8232624-8233446 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:8296475-8297674 Neighboring gene uncharacterized LOC100192426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8367345-8367845 Neighboring gene uncharacterized LOC124904241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8401222-8401752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8406579-8407223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8422085-8422585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8423331-8423954 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:8424831-8425474 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:8425475-8426118 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:8438111-8438317 Neighboring gene COP1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 50, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu. Hoffmann KM, et al. J Biol Chem, 1997 Oct 31. PMID 9346878
    2. Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. Burgoyne AM, et al. Cancer Res, 2009 Sep 1. PMID 19690139, Free PMC Article
    3. PTPmu suppresses glioma cell migration and dispersal. Burgoyne AM, et al. Neuro Oncol, 2009 Dec. PMID 19304959, Free PMC Article
    4. Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia. Hyun SW, et al. Exp Lung Res, 2011 Aug. PMID 21649524, Free PMC Article
    5. Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo. Bianchi C, et al. Exp Cell Res, 1999 Apr 10. PMID 10094839

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG.
      Title: A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG.
    2. Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
      Title: Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
    3. PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling.
      Title: PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling.
    4. High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer.
      Title: High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer.
    5. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.
      Title: PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.
    6. Results suggest increased post-translational modification of RPTPmu N-glycans by GnT-V attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCgamma-PKC pathways.
      Title: β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways.
    7. Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment.
      Title: A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells.
    8. Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival.
      Title: Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis.
    9. Loss of PTPmu by proteolysis causes glioblastoma.
      Title: Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo.
    10. Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression.
      Title: miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
    EBI GWAS Catalog
    Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC166994

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinal ganglion cell axon guidance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase mu
    Names
    protein tyrosine phosphatase mu
    protein tyrosine phosphatase, receptor type, mu polypeptide
    NP_001098714.1
    NP_001365071.1
    NP_001365072.1
    NP_001365073.1
    NP_001365074.1
    NP_001365075.1
    NP_001365076.1
    NP_002836.3
    XP_011524010.1
    XP_011524014.1
    XP_016881383.2
    XP_016881384.2
    XP_016881385.2
    XP_016881386.2
    XP_016881387.2
    XP_016881388.2
    XP_016881389.2
    XP_016881390.2
    XP_016881391.2
    XP_016881392.2
    XP_016881393.2
    XP_016881398.1
    XP_016881399.2
    XP_016881400.1
    XP_016881401.2
    XP_047293670.1
    XP_047293671.1
    XP_047293672.1
    XP_047293673.1
    XP_047293674.1
    XP_047293675.1
    XP_047293676.1
    XP_047293677.1
    XP_047293678.1
    XP_047293679.1
    XP_047293680.1
    XP_054174899.1
    XP_054174900.1
    XP_054174901.1
    XP_054174902.1
    XP_054174903.1
    XP_054174904.1
    XP_054174905.1
    XP_054174906.1
    XP_054174907.1
    XP_054174908.1
    XP_054174909.1
    XP_054174910.1
    XP_054174911.1
    XP_054174912.1
    XP_054174913.1
    XP_054174914.1
    XP_054174915.1
    XP_054174916.1
    XP_054174917.1
    XP_054174918.1
    XP_054174919.1
    XP_054174920.1
    XP_054174921.1
    XP_054174922.1
    XP_054174923.1
    XP_054174924.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105244.2 → NP_001098714.1  receptor-type tyrosine-protein phosphatase mu isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP000897, AP001091, AP001094, AP005118, AP005227, AP005900
      Consensus CDS
      CCDS58613.1
      UniProtKB/TrEMBL
      E7EPS8
      Related
      ENSP00000463325.1, ENST00000580170.6
      Conserved Domains (8) summary
      cd06263
      Location:27 → 182
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:912 → 1166
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:192 → 278
      IG_like; Immunoglobulin like
      cd00047
      Location:939 → 1166
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:499 → 581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    2. NM_001378142.1 → NP_001365071.1  receptor-type tyrosine-protein phosphatase mu isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP001094, AP005118, AP005227, AP005900
      UniProtKB/TrEMBL
      B4DGA3
      Conserved Domains (7) summary
      smart00060
      Location:69 → 148
      FN3; Fibronectin type 3 domain
      cd00063
      Location:170 → 264
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:671 → 943
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1029 → 1234
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain
      pfam18861
      Location:443 → 550
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

    3. NM_001378143.1 → NP_001365072.1  receptor-type tyrosine-protein phosphatase mu isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP001094, AP005118, AP005227, AP005900
      UniProtKB/TrEMBL
      B4DGA3
      Conserved Domains (7) summary
      smart00060
      Location:69 → 148
      FN3; Fibronectin type 3 domain
      cd00063
      Location:170 → 264
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:684 → 956
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1042 → 1247
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain
      pfam18861
      Location:443 → 550
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

    4. NM_001378144.1 → NP_001365073.1  receptor-type tyrosine-protein phosphatase mu isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP001094, AP005118, AP005227, AP005900
      UniProtKB/TrEMBL
      B4DGA3
      Conserved Domains (6) summary
      smart00060
      Location:69 → 148
      FN3; Fibronectin type 3 domain
      cd00063
      Location:170 → 264
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:696 → 968
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1054 → 1259
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain

    5. NM_001378145.1 → NP_001365074.1  receptor-type tyrosine-protein phosphatase mu isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP001094, AP005118, AP005227, AP005900
      UniProtKB/TrEMBL
      B4DGA3
      Conserved Domains (5) summary
      smart00060
      Location:170 → 254
      FN3; Fibronectin type 3 domain
      cd14633
      Location:709 → 981
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1067 → 1272
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain

    6. NM_001378146.1 → NP_001365075.1  receptor-type tyrosine-protein phosphatase mu isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP001094, AP005118, AP005227, AP005900
      UniProtKB/TrEMBL
      B4DGA3
      Conserved Domains (7) summary
      smart00060
      Location:69 → 148
      FN3; Fibronectin type 3 domain
      cd00063
      Location:170 → 264
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:684 → 973
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1059 → 1264
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain
      pfam18861
      Location:443 → 550
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

    7. NM_001378147.1 → NP_001365076.1  receptor-type tyrosine-protein phosphatase mu isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP001094, AP005118, AP005227, AP005900
      UniProtKB/TrEMBL
      B4DGA3
      Conserved Domains (6) summary
      smart00060
      Location:69 → 148
      FN3; Fibronectin type 3 domain
      cd00063
      Location:170 → 264
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:709 → 998
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1084 → 1289
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain

    8. NM_002845.4 → NP_002836.3  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

      See identical proteins and their annotated locations for NP_002836.3

      Status: REVIEWED

      Source sequence(s)
      AC006566, AP000897, AP001091, AP001094, AP005118, AP005227, AP005900
      Consensus CDS
      CCDS11840.1
      UniProtKB/Swiss-Prot
      A7MBN1, D3DUH8, J3QL11, P28827
      UniProtKB/TrEMBL
      E7EPS8
      Related
      ENSP00000331418.8, ENST00000332175.12
      Conserved Domains (8) summary
      cd06263
      Location:27 → 182
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:899 → 1153
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:192 → 278
      IG_like; Immunoglobulin like
      cd00047
      Location:926 → 1153
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:499 → 581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      7567316..8406856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525708.3 → XP_011524010.1  receptor-type tyrosine-protein phosphatase mu isoform X7

      UniProtKB/TrEMBL
      E7EPS8
      Conserved Domains (8) summary
      cd06263
      Location:27 → 182
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:937 → 1208
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:192 → 278
      IG_like; Immunoglobulin like
      cd00047
      Location:964 → 1208
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:499 → 581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    2. XM_047437715.1 → XP_047293671.1  receptor-type tyrosine-protein phosphatase mu isoform X15

    3. XM_011525712.3 → XP_011524014.1  receptor-type tyrosine-protein phosphatase mu isoform X12

      UniProtKB/TrEMBL
      E7EPS8
      Conserved Domains (8) summary
      cd06263
      Location:27 → 182
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:912 → 1183
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:192 → 278
      IG_like; Immunoglobulin like
      cd00047
      Location:939 → 1183
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:499 → 581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    4. XM_047437714.1 → XP_047293670.1  receptor-type tyrosine-protein phosphatase mu isoform X13

    5. XM_047437717.1 → XP_047293673.1  receptor-type tyrosine-protein phosphatase mu isoform X17

    6. XM_047437716.1 → XP_047293672.1  receptor-type tyrosine-protein phosphatase mu isoform X16

    7. XM_047437724.1 → XP_047293680.1  receptor-type tyrosine-protein phosphatase mu isoform X28

    8. XM_017025911.2 → XP_016881400.1  receptor-type tyrosine-protein phosphatase mu isoform X25

      UniProtKB/TrEMBL
      B4E143

    9. XM_047437723.1 → XP_047293679.1  receptor-type tyrosine-protein phosphatase mu isoform X27

    10. XM_017025894.2 → XP_016881383.2  receptor-type tyrosine-protein phosphatase mu isoform X1

    11. XM_017025897.2 → XP_016881386.2  receptor-type tyrosine-protein phosphatase mu isoform X4

    12. XM_017025895.2 → XP_016881384.2  receptor-type tyrosine-protein phosphatase mu isoform X2

    13. XM_017025898.2 → XP_016881387.2  receptor-type tyrosine-protein phosphatase mu isoform X5

    14. XM_017025896.2 → XP_016881385.2  receptor-type tyrosine-protein phosphatase mu isoform X3

    15. XM_017025900.2 → XP_016881389.2  receptor-type tyrosine-protein phosphatase mu isoform X8

    16. XM_017025899.2 → XP_016881388.2  receptor-type tyrosine-protein phosphatase mu isoform X6

    17. XM_017025902.2 → XP_016881391.2  receptor-type tyrosine-protein phosphatase mu isoform X10

    18. XM_017025903.2 → XP_016881392.2  receptor-type tyrosine-protein phosphatase mu isoform X11

    19. XM_017025901.2 → XP_016881390.2  receptor-type tyrosine-protein phosphatase mu isoform X9

    20. XM_017025904.2 → XP_016881393.2  receptor-type tyrosine-protein phosphatase mu isoform X14

      Related
      ENSP00000382927.4, ENST00000400053.8

    21. XM_047437721.1 → XP_047293677.1  receptor-type tyrosine-protein phosphatase mu isoform X22

    22. XM_017025912.2 → XP_016881401.2  receptor-type tyrosine-protein phosphatase mu isoform X26

    23. XM_017025910.2 → XP_016881399.2  receptor-type tyrosine-protein phosphatase mu isoform X23

    24. XM_047437722.1 → XP_047293678.1  receptor-type tyrosine-protein phosphatase mu isoform X24

    25. XM_047437718.1 → XP_047293674.1  receptor-type tyrosine-protein phosphatase mu isoform X18

    26. XM_047437719.1 → XP_047293675.1  receptor-type tyrosine-protein phosphatase mu isoform X19

    27. XM_017025909.2 → XP_016881398.1  receptor-type tyrosine-protein phosphatase mu isoform X21

      UniProtKB/TrEMBL
      B4DGA3

    28. XM_047437720.1 → XP_047293676.1  receptor-type tyrosine-protein phosphatase mu isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      7730572..8570006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318930.1 → XP_054174905.1  receptor-type tyrosine-protein phosphatase mu isoform X7

    2. XM_054318938.1 → XP_054174913.1  receptor-type tyrosine-protein phosphatase mu isoform X15

    3. XM_054318935.1 → XP_054174910.1  receptor-type tyrosine-protein phosphatase mu isoform X12

    4. XM_054318936.1 → XP_054174911.1  receptor-type tyrosine-protein phosphatase mu isoform X13

    5. XM_054318940.1 → XP_054174915.1  receptor-type tyrosine-protein phosphatase mu isoform X17

    6. XM_054318939.1 → XP_054174914.1  receptor-type tyrosine-protein phosphatase mu isoform X16

    7. XM_054318949.1 → XP_054174924.1  receptor-type tyrosine-protein phosphatase mu isoform X28

    8. XM_054318947.1 → XP_054174922.1  receptor-type tyrosine-protein phosphatase mu isoform X25

    9. XM_054318948.1 → XP_054174923.1  receptor-type tyrosine-protein phosphatase mu isoform X27

    10. XM_054318945.1 → XP_054174920.1  receptor-type tyrosine-protein phosphatase mu isoform X23

    11. XM_054318924.1 → XP_054174899.1  receptor-type tyrosine-protein phosphatase mu isoform X29

    12. XM_054318927.1 → XP_054174902.1  receptor-type tyrosine-protein phosphatase mu isoform X32

    13. XM_054318925.1 → XP_054174900.1  receptor-type tyrosine-protein phosphatase mu isoform X30

    14. XM_054318928.1 → XP_054174903.1  receptor-type tyrosine-protein phosphatase mu isoform X33

    15. XM_054318926.1 → XP_054174901.1  receptor-type tyrosine-protein phosphatase mu isoform X31

    16. XM_054318931.1 → XP_054174906.1  receptor-type tyrosine-protein phosphatase mu isoform X35

    17. XM_054318929.1 → XP_054174904.1  receptor-type tyrosine-protein phosphatase mu isoform X34

    18. XM_054318933.1 → XP_054174908.1  receptor-type tyrosine-protein phosphatase mu isoform X37

    19. XM_054318934.1 → XP_054174909.1  receptor-type tyrosine-protein phosphatase mu isoform X38

    20. XM_054318932.1 → XP_054174907.1  receptor-type tyrosine-protein phosphatase mu isoform X36

    21. XM_054318937.1 → XP_054174912.1  receptor-type tyrosine-protein phosphatase mu isoform X39

    22. XM_054318946.1 → XP_054174921.1  receptor-type tyrosine-protein phosphatase mu isoform X40

    23. XM_054318941.1 → XP_054174916.1  receptor-type tyrosine-protein phosphatase mu isoform X18

    24. XM_054318942.1 → XP_054174917.1  receptor-type tyrosine-protein phosphatase mu isoform X19

    25. XM_054318944.1 → XP_054174919.1  receptor-type tyrosine-protein phosphatase mu isoform X21

    26. XM_054318943.1 → XP_054174918.1  receptor-type tyrosine-protein phosphatase mu isoform X20

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28827.2 GenPept UniProtKB/Swiss-Prot:P28827

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