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    DEFB113 defensin beta 113 [ Homo sapiens (human) ]

    Gene ID: 245927, updated on 28-Oct-2024

    Summary

    Official Symbol
    DEFB113provided by HGNC
    Official Full Name
    defensin beta 113provided by HGNC
    Primary source
    HGNC:HGNC:18094
    See related
    Ensembl:ENSG00000214642 AllianceGenome:HGNC:18094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEFB-13
    Summary
    Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
    Orthologs
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    Genomic context

    See DEFB113 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49968677..49969625, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49811571..49812519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49936390..49937338, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene defensin beta 133 (pseudogene) Neighboring gene defensin beta 114 Neighboring gene MPRA-validated peak5843 silencer Neighboring gene defensin beta 110 Neighboring gene defensin beta 112

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General protein information

    Preferred Names
    beta-defensin 113
    Names
    beta-defensin 13
    defensin, beta 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037729.1NP_001032818.1  beta-defensin 113 precursor

      See identical proteins and their annotated locations for NP_001032818.1

      Status: REVIEWED

      Source sequence(s)
      DQ012017
      Consensus CDS
      CCDS43472.1
      UniProtKB/Swiss-Prot
      Q30KQ7
      Related
      ENSP00000381703.1, ENST00000398718.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      49968677..49969625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      49811571..49812519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)