MIR1225 microRNA 1225 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1225provided by HGNC
Official Full Name: microRNA 1225provided by HGNC
Primary source: HGNC:HGNC:33931
See related: Ensembl:ENSG00000221656 MIM:611621; miRBase:MI0006311; AllianceGenome:HGNC:33931
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN1225
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 16p13.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (2090195..2090284, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (2110302..2110391, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (2140196..2140285, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling.
Title: MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling.
Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress.
Title: Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress.
MicroRNA-122-5p alleviates endometrial fibrosis via inhibiting the TGF-beta/SMAD pathway in Asherman's syndrome.
Title: MicroRNA-122-5p alleviates endometrial fibrosis via inhibiting the TGF-β/SMAD pathway in Asherman's syndrome.
The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.
Title: The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.
Overexpression of miR-1225 promotes the progression of breast cancer, resulting in poor prognosis.
Title: Overexpression of miR-1225 promotes the progression of breast cancer, resulting in poor prognosis.
Downregulation of miR-1225-5p is pivotal for proliferation, invasion, and migration of HCC cells through NFkappaB regulation.
Title: Downregulation of miR-1225-5p is pivotal for proliferation, invasion, and migration of HCC cells through NFκB regulation.
Long non-coding RNA DANCR promoted non-small cell lung cancer cells metastasis via modulating of miR-1225-3p/ErbB2 signal.
Title: Long non-coding RNA DANCR promoted non-small cell lung cancer cells metastasis via modulating of miR-1225-3p/ErbB2 signal.
Functional classification of prostate cancerassociated miRNAs through CRISPR/Cas9mediated gene knockout.
Title: Functional classification of prostate cancer‑associated miRNAs through CRISPR/Cas9‑mediated gene knockout.
Expression of miR-1225 was upregulated in pancreatic cancer cells and in specimens from patients suffering from pancreatic cancer. MiR-1225 inhibition impaired the proliferation of pancreatic cancer cells in vitro and in vivo and suppressed the tumor growth.
Title: microRNA-1225 inhibit apoptosis of pancreatic cancer cells via targeting JAK1.
MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
Title: MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.