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    UPS2 Ups2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850865, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPS2
    Official Full Name
    Ups2p
    Primary source
    SGD:S000004158
    Locus tag
    YLR168C
    See related
    AllianceGenome:SGD:S000004158; FungiDB:YLR168C; VEuPathDB:YLR168C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM30; GEP1; MSF1; MSF1'
    Summary
    Predicted to enable phosphatidic acid transfer activity. Involved in several processes, including cristae formation; glycerophospholipid metabolic process; and negative regulation of phosphatidylcholine biosynthetic process. Located in mitochondrial intermembrane space. Is extrinsic component of mitochondrial inner membrane. Orthologous to human PRELID3A (PRELI domain containing 3A) and PRELID3B (PRELI domain containing 3B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UPS2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (499578..500270, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene exocyst subunit SEC10 Neighboring gene ubiquitin-ribosomal 40S subunit protein S31 fusion protein Neighboring gene Aps1p Neighboring gene diphthine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast. Leonov A, et al. Oncotarget, 2017 May 9. PMID 28410198, Free PMC Article
    2. Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria. Miyata N, et al. J Cell Biol, 2016 Jul 4. PMID 27354379, Free PMC Article
    3. Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria. Hall BM, et al. J Biol Chem, 2011 Nov 11. PMID 21930701, Free PMC Article
    4. Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport. Kojima R, et al. Cell Rep, 2019 Jan 15. PMID 30650346, Free PMC Article
    5. MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. Aaltonen MJ, et al. J Cell Biol, 2016 Jun 6. PMID 27241913, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane
      Title: Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P.
    2. Data suggest that Ups1p and Up2p proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes.
      Title: Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking.
    3. The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
      Title: Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
    4. The authors identified Mdm35, a member of the twin Cx9C protein family, as a novel interaction partner of Ups1 and Ups2.
      Title: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
    5. Data report that two homologous intermembrane space proteins, Ups1p and Ups2p, control cardiolipin metabolism and affect the assembly state of TIM23 and its association with PAM in an opposing manner.
      Title: Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidic acid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cristae formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ups2p
    NP_013269.1
    • Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      499578..500270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182055.1 → NP_013269.1  TPA: Ups2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013269.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYH4, P35200
      UniProtKB/TrEMBL
      A7A161, B3RH63, B5VN88, C7GIW0, C8ZDE1, G2WJ03, N1NZC9
      Conserved Domains (1) summary
      pfam04707
      Location:15 → 172
      PRELI; PRELI-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35200.1

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