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    Ets2 ETS proto-oncogene 2, transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304063, updated on 28-Oct-2024

    Summary

    Official Symbol
    Ets2provided by RGD
    Official Full Name
    ETS proto-oncogene 2, transcription factorprovided by RGD
    Primary source
    RGD:1584977
    See related
    EnsemblRapid:ENSRNOG00000001647 AllianceGenome:RGD:1584977
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA binding activity and nuclear glucocorticoid receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human ETS2 (ETS proto-oncogene 2, transcription factor). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Lung (RPKM 155.5), Kidney (RPKM 147.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ets2 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48491057..48507843)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35021536..35038322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36075709..36092495)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ETS transcription factor ERG Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095640 Neighboring gene uncharacterized LOC103693523 Neighboring gene uncharacterized LOC108352314

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein C-ets-2
    Names
    E26 avian leukemia oncogene 2, 3' domain
    avian erythroblastosis virus E26 (v-ets) oncogene homolog 2
    v-ets avian erythroblastosis virus E26 oncogene homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107107.1NP_001100577.2  protein C-ets-2

      See identical proteins and their annotated locations for NP_001100577.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6GB76, A6KPT9
      Conserved Domains (2) summary
      cd08543
      Location:85173
      SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
      smart00413
      Location:363447
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48491057..48507843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248177.4XP_006248239.1  protein C-ets-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZS11, A0A8I6GB76
      Related
      ENSRNOP00000079943.1, ENSRNOT00000110500.2
      Conserved Domains (2) summary
      cd08543
      Location:109197
      SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
      smart00413
      Location:387471
      ETS; erythroblast transformation specific domain