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    ZNF605 zinc finger protein 605 [ Homo sapiens (human) ]

    Gene ID: 100289635, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF605provided by HGNC
    Official Full Name
    zinc finger protein 605provided by HGNC
    Primary source
    HGNC:HGNC:28068
    See related
    Ensembl:ENSG00000196458 AllianceGenome:HGNC:28068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Annotation information
    Note: ZNF605 was originally represented by geneID:90462, and is located at chromosome 12q24.33. For NCBI Build 36.3, geneID:90462 was misplaced on the unplaced chr 12 contig NT_167217.1, and geneID:100289635 was created to represent the chr 12 location. This error was fixed in September 2009 by renaming geneID:100289635 as ZNF605. [13 Feb 2013]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.2), ovary (RPKM 3.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF605 in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132918306..132956306, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132969080..133013678, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133494892..133532892, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26180 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5132 Neighboring gene uncharacterized LOC124903065 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133531610-133532440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133532441-133533269 Neighboring gene uncharacterized LOC124903064 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:133553507-133553757 Neighboring gene NANOGNB pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133563299-133563798 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene zinc finger protein 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The full-ORF clone resource of the German cDNA Consortium. Bechtel S, et al. BMC Genomics, 2007 Oct 31. PMID 17974005, Free PMC Article
    2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206
    4. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CHFR

    Homology

    Clone Names

    • FLJ14967, FLJ16520, DKFZp686B222, DKFZp451B1818

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 605

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164715.2 → NP_001158187.1  zinc finger protein 605 isoform 2

      See identical proteins and their annotated locations for NP_001158187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) includes an alternate segment, compared to isoform 1.
      Source sequence(s)
      AC127070, AK122878, BF476024
      Consensus CDS
      CCDS53850.1
      UniProtKB/Swiss-Prot
      Q86T29
      Related
      ENSP00000376135.3, ENST00000392321.3
      Conserved Domains (6) summary
      smart00349
      Location:7 → 65
      KRAB; krueppel associated box
      COG5048
      Location:199 → 603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:230 → 250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:620 → 642
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:7 → 45
      KRAB; KRAB box
      pfam13465
      Location:551 → 575
      zf-H2C2_2; Zinc-finger double domain

    2. NM_183238.4 → NP_899061.1  zinc finger protein 605 isoform 1

      See identical proteins and their annotated locations for NP_899061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AC073911, AC127070, AL832191, BF476024
      Consensus CDS
      CCDS31938.1
      UniProtKB/Swiss-Prot
      B3KVG4, D3DXJ0, Q86T29, Q86T91
      Related
      ENSP00000353314.3, ENST00000360187.9
      Conserved Domains (6) summary
      smart00349
      Location:7 → 46
      KRAB; krueppel associated box
      COG5048
      Location:168 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:199 → 219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:589 → 611
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:7 → 45
      KRAB; KRAB box
      pfam13465
      Location:520 → 544
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      132918306..132956306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      132969080..133013678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86T29.1 GenPept UniProtKB/Swiss-Prot:Q86T29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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