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    SNRPB2 small nuclear ribonucleoprotein polypeptide B2 [ Homo sapiens (human) ]

    Gene ID: 6629, updated on 17-Jun-2024

    Summary

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    Official Symbol
    SNRPB2provided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide B2provided by HGNC
    Primary source
    HGNC:HGNC:11155
    See related
    Ensembl:ENSG00000125870 MIM:603520; AllianceGenome:HGNC:11155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Msl1; U2B''
    Summary
    The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 22.1), appendix (RPKM 20.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SNRPB2 in Genome Data Viewer
    Location:
    20p12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (16730026..16742564)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (16781147..16793686)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (16710671..16723209)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372542 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:16605418-16605990 Neighboring gene ribosomal protein L7a pseudogene 13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59901 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:16709782-16710650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12684 Neighboring gene otoraplin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:16911071-16911646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:16956495-16957021 Neighboring gene uncharacterized LOC124904984

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nuclear exchange of the U1 and U2 snRNP-specific proteins. Feeney RJ, et al. J Cell Biol, 1990 Apr. PMID 2139037, Free PMC Article
    2. Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles. Moraitou M, et al. Biochem J, 1998 May 15. PMID 9576861, Free PMC Article
    3. U2-snRNP B" protein gene is an early growth-inducible gene. Laitinen J, et al. J Cell Biochem, 1995 Aug. PMID 7593271
    4. Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. Habets WJ, et al. Proc Natl Acad Sci U S A, 1987 Apr. PMID 2951739, Free PMC Article
    5. Binding affinity and cooperativity control U2B″/snRNA/U2A' RNP formation. Williams SG, et al. Biochemistry, 2014 Jun 17. PMID 24866816, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat U2 snRNPs interact with the HIV-1 Tat cofactor TAT-SF1 and stimulate transcription from the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC24807, MGC45309

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in U2-type prespliceosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U2 small nuclear ribonucleoprotein B''
    Names
    U2 snRNP B''
    small nuclear ribonucleoprotein polypeptide B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003092.5 → NP_003083.1  U2 small nuclear ribonucleoprotein B''

      See identical proteins and their annotated locations for NP_003083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI741327, AL034428, BC018022, BM772256
      Consensus CDS
      CCDS13123.1
      UniProtKB/Swiss-Prot
      B2R7J3, D3DW21, P08579, Q9UJD4
      UniProtKB/TrEMBL
      B5BTZ8
      Related
      ENSP00000246071.6, ENST00000246071.8
      Conserved Domains (2) summary
      cd12481
      Location:146 → 225
      RRM2_U2B; RNA recognition motif 2 (RRM2) found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")
      cd12478
      Location:6 → 96
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins

    2. NM_198220.3 → NP_937863.1  U2 small nuclear ribonucleoprotein B''

      See identical proteins and their annotated locations for NP_937863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI741327, AL034428, BC036737, BM772256, DA088017
      Consensus CDS
      CCDS13123.1
      UniProtKB/Swiss-Prot
      B2R7J3, D3DW21, P08579, Q9UJD4
      UniProtKB/TrEMBL
      B5BTZ8
      Related
      ENSP00000367178.5, ENST00000377943.9
      Conserved Domains (2) summary
      cd12481
      Location:146 → 225
      RRM2_U2B; RNA recognition motif 2 (RRM2) found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")
      cd12478
      Location:6 → 96
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      16730026..16742564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      16781147..16793686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08579.1 GenPept UniProtKB/Swiss-Prot:P08579

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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