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    USP17L6P ubiquitin specific peptidase 17 like family member 6, pseudogene [ Homo sapiens (human) ]

    Gene ID: 391622, updated on 2-Nov-2024

    Summary

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    Official Symbol
    USP17L6Pprovided by HGNC
    Official Full Name
    ubiquitin specific peptidase 17 like family member 6, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:37179
    See related
    Ensembl:ENSG00000205946 AllianceGenome:HGNC:37179
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUB4; vDUB4; USP17L6
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See USP17L6P in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (9367874..9369070)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (9388397..9389593)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9369600..9370796)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 17 like family member 9, pseudogene Neighboring gene ubiquitin specific peptidase 17 like family member 30 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:9382887-9383424 Neighboring gene zinc finger protein 705A-like Neighboring gene defensin beta 108F (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc25A and Dub3 in a high-stakes balancing act. Hayes SD, et al. Nat Cell Biol, 2010 Apr. PMID 20228807
    2. Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. Gondo Y, et al. Genomics, 1998 Nov 15. PMID 9806828
    3. The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. Saitoh Y, et al. Genomics, 2000 Aug 1. PMID 10936051
    4. Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. Okada T, et al. Hum Genet, 2002 Apr. PMID 11941478
    5. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. Shin JM, et al. BMC Genomics, 2006 Nov 16. PMID 17109758, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • chorionic villi deubiquitinating enzyme
    • deubiquitinating enzyme DUB4
    • ubiquitin specific peptidase 17-like 6 (pseudogene)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in regulation of epithelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027279.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116655
      Related
      ENST00000382470.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      9367874..9369070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      9388397..9389593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212553.1: Suppressed sequence

      Description
      NM_212553.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QN14.2 GenPept UniProtKB/Swiss-Prot:Q6QN14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials