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    LRRC66 leucine rich repeat containing 66 [ Homo sapiens (human) ]

    Gene ID: 339977, updated on 2-Nov-2024

    Summary

    Official Symbol
    LRRC66provided by HGNC
    Official Full Name
    leucine rich repeat containing 66provided by HGNC
    Primary source
    HGNC:HGNC:34299
    See related
    Ensembl:ENSG00000188993 AllianceGenome:HGNC:34299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017]
    Expression
    Biased expression in duodenum (RPKM 4.6), small intestine (RPKM 4.1) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LRRC66 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (51993652..52020363, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (55479597..55506301, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (52859818..52886529, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene deoxyuridine triphosphatase pseudogene 7 Neighboring gene ribosomal protein L37a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15421 Neighboring gene sarcoglycan beta Neighboring gene long intergenic non-protein coding RNA 2480

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in long-term memory IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 66

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053164.1 RefSeqGene

      Range
      4949..31660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024611.3NP_001019782.1  leucine-rich repeat-containing protein 66 precursor

      See identical proteins and their annotated locations for NP_001019782.1

      Status: REVIEWED

      Source sequence(s)
      AC093858, BU620718, CA436716, CR749811
      Consensus CDS
      CCDS43229.1
      UniProtKB/Swiss-Prot
      Q68CR7
      Related
      ENSP00000508002.1, ENST00000682860.1
      Conserved Domains (3) summary
      cd00116
      Location:60255
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:88110
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:171231
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      51993652..52020363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415645.1XP_047271601.1  leucine-rich repeat-containing protein 66 isoform X2

    2. XM_047415644.1XP_047271600.1  leucine-rich repeat-containing protein 66 isoform X1

    3. XM_047415646.1XP_047271602.1  leucine-rich repeat-containing protein 66 isoform X3

    4. XM_047415647.1XP_047271603.1  leucine-rich repeat-containing protein 66 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      55479597..55506301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349929.1XP_054205904.1  leucine-rich repeat-containing protein 66 isoform X2

    2. XM_054349928.1XP_054205903.1  leucine-rich repeat-containing protein 66 isoform X1

    3. XM_054349930.1XP_054205905.1  leucine-rich repeat-containing protein 66 isoform X3

    4. XM_054349931.1XP_054205906.1  leucine-rich repeat-containing protein 66 isoform X3