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    HOXA11-AS HOXA11 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 221883, updated on 4-Nov-2024

    Summary

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    Official Symbol
    HOXA11-ASprovided by HGNC
    Official Full Name
    HOXA11 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:24957
    See related
    Ensembl:ENSG00000240990 MIM:607530; AllianceGenome:HGNC:24957
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOXA11S; HOXA-AS5; HOXA11AS; LncHOXA11; HOXA11-AS1; NCRNA00076
    Summary
    This gene produces a long non-coding RNA in antisense to transcription of the homeobox A11 gene. This transcript may associate with chromatin factors such as Polycomb repressive complex and act as a sponge for microRNAs, thereby participating in the regulation of expression of target genes. High levels of this transcript may be associated with tumor progression. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in prostate (RPKM 18.6), endometrium (RPKM 8.7) and 3 other tissues See more
    Orthologs
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    Genomic context

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    See HOXA11-AS in Genome Data Viewer
    Location:
    7p15.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (27185408..27189293)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (27321416..27325300)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27225027..27228912)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene HOXA10 antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27211139-27211638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27213347-27213993 Neighboring gene homeobox A10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27213994-27214639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27218758-27219360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27219361-27219962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27222450-27223332 Neighboring gene NUP98-HOXA11 recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27223333-27224214 Neighboring gene homeobox A11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27225097-27225978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27231749-27232306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27232307-27232864 Neighboring gene homeobox A13 Neighboring gene NUP98-HOXA13 recombination region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27242057-27242581 Neighboring gene HOXA distal transcript antisense RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244076-27244800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244801-27245523

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Over-expressed long noncoding RNA HOXA11-AS promotes cell cycle progression and metastasis in gastric cancer. Liu Z, et al. Mol Cancer, 2017 Apr 26. PMID 28441948, Free PMC Article
    2. Promotion of LncRNA HOXA11-AS on the proliferation of hepatocellular carcinoma by regulating the expression of LATS1. Yu J, et al. Eur Rev Med Pharmacol Sci, 2017 Aug. PMID 28829501
    3. Long non-coding RNA HOXA11-AS in human cancer: A meta-analysis. Li N, et al. Clin Chim Acta, 2017 Nov. PMID 28942241
    4. Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer. Su JC, et al. Mol Med Rep, 2017 Oct. PMID 28791375
    5. Aberrant Expression of lncRNA ( HOXA11-AS1) and Homeobox A ( HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women With Endometriosis. Wang M, et al. Reprod Sci, 2018 May. PMID 29017417

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of long noncoding RNA HOXA11-AS nullifies the impact of microRNA-506-3p on chondrocytes proliferation and apoptosis in osteoarthritis.
      Title: Down-regulation of long noncoding RNA HOXA11-AS nullifies the impact of microRNA-506-3p on chondrocytes proliferation and apoptosis in osteoarthritis.
    2. LncRNA HOXA11-AS modulates the miR-148b-3p/MLPH axis to promote prostate cancer cell proliferation.
      Title: LncRNA HOXA11-AS modulates the miR-148b-3p/MLPH axis to promote prostate cancer cell proliferation.
    3. The long noncoding RNA HOXA11-AS promotes lung adenocarcinoma proliferation and glycolysis via the microRNA-148b-3p/PKM2 axis.
      Title: The long noncoding RNA HOXA11-AS promotes lung adenocarcinoma proliferation and glycolysis via the microRNA-148b-3p/PKM2 axis.
    4. An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.
      Title: An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.
    5. The minor allele of rs17427875 in long non-coding RNA-HOXA11-AS influences the prognosis of subarachnoid hemorrhage (SAH) via modulating miR-15a and STAT3 expression.
      Title: The minor allele of rs17427875 in long non-coding RNA-HOXA11-AS influences the prognosis of subarachnoid hemorrhage (SAH) via modulating miR-15a and STAT3 expression.
    6. Long non-coding RNA HOXA11-AS knockout inhibits proliferation and overcomes drug resistance in ovarian cancer.
      Title: Long non-coding RNA HOXA11-AS knockout inhibits proliferation and overcomes drug resistance in ovarian cancer.
    7. Increased expression of HOXA11-AS attenuates endometrial decidualization in recurrent implantation failure patients.
      Title: Increased expression of HOXA11-AS attenuates endometrial decidualization in recurrent implantation failure patients.
    8. Uterine HOXA11 antisense long non-coding RNA prevents decidualization: A new pathway-regulating pregnancy.
      Title: Uterine HOXA11 antisense long non-coding RNA prevents decidualization: A new pathway-regulating pregnancy.
    9. Long noncoding HOXA11-AS knockdown suppresses the progression of non-small cell lung cancer by regulating miR-3619-5p/SALL4 axis.
      Title: Long noncoding HOXA11-AS knockdown suppresses the progression of non-small cell lung cancer by regulating miR-3619-5p/SALL4 axis.
    10. LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
      Title: LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • HOXA cluster antisense RNA 5 (non-protein coding)
    • HOXA11 antisense RNA 1 (non-protein coding)
    • homeo box A11, opposite strand transcript
    • homeobox A11 antisense

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002795.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC025338, BI753022, DA421792
      Related
      ENST00000522674.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      27185408..27189293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      27321416..27325300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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