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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001195643.2 → NP_001182572.1 dihydrofolate reductase 2, mitochondrial
See identical proteins and their annotated locations for NP_001182572.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
- Source sequence(s)
-
AC130896, AW104373
- Consensus CDS
-
CCDS2926.1
- UniProtKB/Swiss-Prot
- D3DN30, Q6P4I9, Q86XF0
- Related
- ENSP00000377768.2, ENST00000394221.3
- Conserved Domains (1) summary
-
- cd00209
Location:5 → 182
- DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
-
NM_176815.5 → NP_789785.1 dihydrofolate reductase 2, mitochondrial
See identical proteins and their annotated locations for NP_789785.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) differs in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
- Source sequence(s)
-
AC130896, AW104373
- Consensus CDS
-
CCDS2926.1
- UniProtKB/Swiss-Prot
- D3DN30, Q6P4I9, Q86XF0
- Related
- ENSP00000319170.2, ENST00000314636.3
- Conserved Domains (1) summary
-
- cd00209
Location:5 → 182
- DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12 Reference GRCh38.p14 Primary Assembly
- Range
-
94057922..94063320 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011512537.4 → XP_011510839.1 dihydrofolate reductase 2, mitochondrial isoform X1
See identical proteins and their annotated locations for XP_011510839.1
- UniProtKB/Swiss-Prot
- D3DN30, Q6P4I9, Q86XF0
- Conserved Domains (1) summary
-
- cd00209
Location:5 → 182
- DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1 Alternate T2T-CHM13v2.0
- Range
-
96756374..96761771 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054345627.1 → XP_054201602.1 dihydrofolate reductase 2, mitochondrial isoform X1
- UniProtKB/TrEMBL
-
B3KV46