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    Anxa10 annexin A10 [ Mus musculus (house mouse) ]

    Gene ID: 26359, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Anxa10provided by MGI
    Official Full Name
    annexin A10provided by MGI
    Primary source
    MGI:MGI:1347090
    See related
    Ensembl:ENSMUSG00000031635 AllianceGenome:MGI:1347090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Located in mitochondrion. Orthologous to human ANXA10 (annexin A10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward stomach adult (RPKM 61.0) See more
    Orthologs
    human all
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    Genomic context

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    See Anxa10 in Genome Data Viewer
    Location:
    8 B3.1; 8 31.55 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (62510076..62576227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (62057042..62123193, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene DExD/H box helicase 60 Neighboring gene STARR-seq mESC enhancer starr_21603 Neighboring gene STARR-seq mESC enhancer starr_21604 Neighboring gene STARR-seq mESC enhancer starr_21605 Neighboring gene STARR-seq mESC enhancer starr_21607 Neighboring gene predicted gene 2961 Neighboring gene STARR-seq mESC enhancer starr_21609 Neighboring gene STARR-seq mESC enhancer starr_21610 Neighboring gene STARR-seq mESC enhancer starr_21611 Neighboring gene STARR-seq mESC enhancer starr_21612 Neighboring gene STARR-seq mESC enhancer starr_21613 Neighboring gene STARR-seq mESC enhancer starr_21614 Neighboring gene heat shock protein 1 (chaperonin), pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number variation is associated with embryonic mortality in Japanese Black cattle. Sasaki S, et al. BMC Genomics, 2016 Nov 24. PMID 27881083, Free PMC Article
    2. Annexin A10 is involved in the development and maintenance of neuropathic pain in mice. Lu Y, et al. Neurosci Lett, 2016 Sep 19. PMID 27507697
    3. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure. Motomura K, et al. Diabetes, 2024 Jan 1. PMID 37871012, Free PMC Article
    4. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer. Wang X, et al. Cell Death Dis, 2023 Sep 4. PMID 37666806, Free PMC Article
    5. Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3- mutant mice. Yamamoto A, et al. Dev Neurosci, 2014. PMID 25138526

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward beta-Cell Failure.
      Title: Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure.
    2. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.
      Title: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.
    3. Spinal nerve ligation (SNL) induced persistent upregulation of annexin A10 mRNA and protein in the spinal cord of mice. annexin A10 siRNA partially prevented SNL-induced mechanical allodynia and heat hyperalgesia. Findings suggest that annexin A10 might be a novel target in the treatment of neuropathic pain.
      Title: Annexin A10 is involved in the development and maintenance of neuropathic pain in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159022

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    annexin A10
    Names
    annexin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136089.2 → NP_001129561.1  annexin A10 isoform 1

      See identical proteins and their annotated locations for NP_001129561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK131880, AK168715, BY083459
      Consensus CDS
      CCDS52558.1
      UniProtKB/Swiss-Prot
      Q3TGJ1, Q9QZ10
      UniProtKB/TrEMBL
      Q3V2F1
      Related
      ENSMUSP00000034052.7, ENSMUST00000034052.14
      Conserved Domains (1) summary
      pfam00191
      Location:93 → 158
      Annexin

    2. NM_011922.3 → NP_036052.2  annexin A10 isoform 2

      See identical proteins and their annotated locations for NP_036052.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK020288, AK131880, BY083459
      Consensus CDS
      CCDS52557.1
      UniProtKB/TrEMBL
      Q3V2F1, Q9D272
      Related
      ENSMUSP00000034054.8, ENSMUST00000034054.9
      Conserved Domains (2) summary
      pfam00191
      Location:231 → 296
      Annexin; Annexin
      cl02574
      Location:106 → 131
      Annexin; Annexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      62510076..62576227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ10.2 GenPept UniProtKB/Swiss-Prot:Q9QZ10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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