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    Pdzd11 PDZ domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 72621, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pdzd11provided by MGI
    Official Full Name
    PDZ domain containing 11provided by MGI
    Primary source
    MGI:MGI:1919871
    See related
    Ensembl:ENSMUSG00000015668 AllianceGenome:MGI:1919871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdzk11; 1810012H22Rik; 2310079D11Rik; 2700099C19Rik
    Summary
    Predicted to enable enzyme activator activity; protein-macromolecule adaptor activity; and transporter activator activity. Involved in pore complex assembly. Part of pore complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human PDZD11 (PDZ domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.4), placenta adult (RPKM 20.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pdzd11 in Genome Data Viewer
    Location:
    X C3; X 43.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99665949..99673667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100622871..100625948, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47635 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 Neighboring gene arrestin 3, retinal Neighboring gene kinesin family member 4 Neighboring gene predicted gene, 52438 Neighboring gene STARR-seq mESC enhancer starr_47636 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene predicted gene 14866

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter. Nabokina SM, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Apr. PMID 21183659, Free PMC Article
    2. PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. Guerrera D, et al. J Biol Chem, 2016 May 20. PMID 27044745, Free PMC Article
    3. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Shah J, et al. Cell Rep, 2018 Nov 20. PMID 30463011
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transporter activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biotin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in pore complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PDZ domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356384.1 → NP_001343313.1  PDZ domain-containing protein 11

      Status: VALIDATED

      Source sequence(s)
      AK007454, BP772832, BX276129, CB316786
      Consensus CDS
      CCDS30304.1
      UniProtKB/Swiss-Prot
      Q9CZG9
      Related
      ENSMUSP00000015812.6, ENSMUST00000015812.12
      Conserved Domains (1) summary
      cd00992
      Location:45 → 125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_028303.4 → NP_082579.1  PDZ domain-containing protein 11

      See identical proteins and their annotated locations for NP_082579.1

      Status: VALIDATED

      Source sequence(s)
      AK012624, BP772832, BX276129
      Consensus CDS
      CCDS30304.1
      UniProtKB/Swiss-Prot
      Q9CZG9
      Related
      ENSMUSP00000051068.7, ENSMUST00000059099.7
      Conserved Domains (1) summary
      cd00992
      Location:45 → 125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      99665949..99673667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162102.1 → XP_036017995.1  PDZ domain-containing protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZG9
      Conserved Domains (1) summary
      cd00992
      Location:45 → 125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. XM_011247685.2 → XP_011245987.1  PDZ domain-containing protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011245987.1

      UniProtKB/Swiss-Prot
      Q9CZG9
      Conserved Domains (1) summary
      cd00992
      Location:45 → 125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZG9.1 GenPept UniProtKB/Swiss-Prot:Q9CZG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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