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    Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase 5 [ Mus musculus (house mouse) ]

    Gene ID: 83965, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Enpp5provided by MGI
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 5provided by MGI
    Primary source
    MGI:MGI:1933830
    See related
    Ensembl:ENSMUSG00000023960 AllianceGenome:MGI:1933830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E-NPP 5; D17Abb1e
    Summary
    Enables zinc ion binding activity. Predicted to be involved in cell communication. Predicted to act upstream of or within nucleotide catabolic process. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Orthologous to human ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 114.0), cerebellum adult (RPKM 52.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Enpp5 in Genome Data Viewer
    Location:
    17 B3; 17 20.3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (44389693..44397458)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (44078802..44086567)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene STARR-seq mESC enhancer starr_42606 Neighboring gene STARR-seq mESC enhancer starr_42607 Neighboring gene predicted gene, 34857 Neighboring gene predicted gene, 34917 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 4 Neighboring gene chloride intracellular channel 5 Neighboring gene STARR-seq mESC enhancer starr_42608 Neighboring gene STARR-positive B cell enhancer ABC_E5611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Ohe Y, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927778
    2. Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging. Takaya K, et al. Biogerontology, 2024 Jun. PMID 38436793
    3. A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5. Gorelik A, et al. FEBS J, 2017 Nov. PMID 28898552
    4. Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. Kasowitz SD, et al. PLoS Genet, 2018 May. PMID 29799838, Free PMC Article
    5. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging.
      Title: Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4152

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dinucleotide phosphatase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide catabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 5
    NP_001162091.1
    NP_001316547.1
    NP_001316548.1
    NP_001316549.1
    NP_001316550.1
    NP_001316551.1
    NP_114392.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168620.2 → NP_001162091.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001162091.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF233377, AK032341, BC089320, BY232106, CT030230
      Consensus CDS
      CCDS28802.1
      UniProtKB/Swiss-Prot
      A9C479, Q921P7, Q9EQG7
      UniProtKB/TrEMBL
      Q5DTL0
      Related
      ENSMUSP00000122767.2, ENSMUST00000154166.8
      Conserved Domains (2) summary
      pfam01663
      Location:30 → 342
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:28 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. NM_001329618.1 → NP_001316547.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK032341, BC089320, BY232106, CT030230
      UniProtKB/TrEMBL
      Q5DTL0
      Conserved Domains (2) summary
      pfam01663
      Location:17 → 273
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:17 → 313
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. NM_001329619.1 → NP_001316548.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AF233377, BC089320, BY252780, CT030230
      UniProtKB/Swiss-Prot
      Q9EQG7
      UniProtKB/TrEMBL
      Q5FWJ8

    4. NM_001329620.1 → NP_001316549.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      BC089320, BC145484, BY252780, CT030230
      UniProtKB/TrEMBL
      Q5FWJ8

    5. NM_001329621.1 → NP_001316550.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BC089320, BY257129, CT030230
      UniProtKB/TrEMBL
      Q5FWJ8

    6. NM_001329622.1 → NP_001316551.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BC089320, BY232106, CT030230
      UniProtKB/TrEMBL
      Q5FWJ8

    7. NM_032003.3 → NP_114392.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_114392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF233377, BC089320, BY252780, CT030230
      Consensus CDS
      CCDS28802.1
      UniProtKB/Swiss-Prot
      A9C479, Q921P7, Q9EQG7
      UniProtKB/TrEMBL
      Q5DTL0
      Related
      ENSMUSP00000024756.5, ENSMUST00000024756.5
      Conserved Domains (2) summary
      pfam01663
      Location:30 → 342
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:28 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      44389693..44397458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQG7.3 GenPept UniProtKB/Swiss-Prot:Q9EQG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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