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    Nadsyn1 NAD synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 78914, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nadsyn1provided by MGI
    Official Full Name
    NAD synthetase 1provided by MGI
    Primary source
    MGI:MGI:1926164
    See related
    Ensembl:ENSMUSG00000031090 AllianceGenome:MGI:1926164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130012B15Rik
    Summary
    Predicted to enable NAD+ synthase (glutamine-hydrolyzing) activity; NAD+ synthase activity; and glutaminase activity. Predicted to be involved in 'de novo' NAD biosynthetic process. Predicted to be active in cytoplasm. Is expressed in alimentary system; liver; male reproductive gland or organ; metanephros; and nervous system. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 18.4), large intestine adult (RPKM 18.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nadsyn1 in Genome Data Viewer
    Location:
    7 F5; 7 88.32 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143349326..143376598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143795589..143822862, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member G Neighboring gene MAS-related GPR, member E Neighboring gene STARR-positive B cell enhancer ABC_E1750 Neighboring gene STARR-positive B cell enhancer ABC_E2257 Neighboring gene STARR-positive B cell enhancer ABC_E3763 Neighboring gene 7-dehydrocholesterol reductase Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:151023918-151024190 Neighboring gene STARR-seq mESC enhancer starr_20537 Neighboring gene actin, epsilon 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. Marin TL, et al. BMC Syst Biol, 2015 Mar 11. PMID 25890336, Free PMC Article
    2. A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder. Szot JO, et al. J Clin Invest, 2024 Feb 15. PMID 38357931, Free PMC Article
    3. Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. Hara N, et al. J Biol Chem, 2003 Mar 28. PMID 12547821
    4. BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities. Yaku K, et al. Nat Commun, 2021 Nov 19. PMID 34799586, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.
      Title: A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables NAD+ synthase (glutamine-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD+ synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 'de novo' NAD biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamine-dependent NAD(+) synthetase
    Names
    NAD(+) synthase
    NH3-dependent NAD(+) synthetase-like protein
    NP_001295024.1
    NP_084497.1
    XP_006508718.1
    XP_011240323.1
    XP_011240325.1
    XP_017167890.1
    XP_030098977.1
    XP_030098978.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308095.1 → NP_001295024.1  glutamine-dependent NAD(+) synthetase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in its 5' UTR, resulting in the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK020264, BQ176832, BY035654
      UniProtKB/Swiss-Prot
      Q711T7
      Conserved Domains (1) summary
      PLN02339
      Location:1 → 451
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    2. NM_030221.2 → NP_084497.1  glutamine-dependent NAD(+) synthetase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK020264, BQ176832, BY035654
      Consensus CDS
      CCDS22047.1
      UniProtKB/Swiss-Prot
      Q711P6, Q711T7, Q8CFY6, Q9D280
      Related
      ENSMUSP00000033415.9, ENSMUST00000033415.15
      Conserved Domains (3) summary
      cd07570
      Location:6 → 287
      GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
      PLN02339
      Location:3 → 697
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
      cd00553
      Location:328 → 650
      NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143349326..143376598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243118.2 → XP_030098978.1  glutamine-dependent NAD(+) synthetase isoform X5

      Conserved Domains (1) summary
      PLN02339
      Location:1 → 451
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    2. XM_011242021.4 → XP_011240323.1  glutamine-dependent NAD(+) synthetase isoform X1

      UniProtKB/Swiss-Prot
      Q711T7
      Conserved Domains (1) summary
      PLN02339
      Location:1 → 610
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    3. XM_017312401.3 → XP_017167890.1  glutamine-dependent NAD(+) synthetase isoform X2

      Conserved Domains (1) summary
      PLN02339
      Location:1 → 583
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    4. XM_030243117.2 → XP_030098977.1  glutamine-dependent NAD(+) synthetase isoform X5

      Conserved Domains (1) summary
      PLN02339
      Location:1 → 451
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    5. XM_006508655.5 → XP_006508718.1  glutamine-dependent NAD(+) synthetase isoform X3

      UniProtKB/TrEMBL
      G5E8V4
      Related
      ENSMUSP00000114380.2, ENSMUST00000132520.8
      Conserved Domains (1) summary
      PLN02339
      Location:3 → 485
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    6. XM_011242023.4 → XP_011240325.1  glutamine-dependent NAD(+) synthetase isoform X4

      UniProtKB/TrEMBL
      G5E8V4
      Conserved Domains (1) summary
      PLN02339
      Location:3 → 486
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    RNA

    1. XR_378612.4 RNA Sequence

    2. XR_004934222.1 RNA Sequence

      Related
      ENSMUST00000156638.8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001308092.1: Suppressed sequence

      Description
      NM_001308092.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q711T7.1 GenPept UniProtKB/Swiss-Prot:Q711T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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