Bpifb3 BPI fold containing family B, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpifb3provided by MGI
Official Full Name: BPI fold containing family B, member 3provided by MGI
Primary source: MGI:MGI:2675077
See related: Ensembl:ENSMUSG00000068008 AllianceGenome:MGI:2675077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rya3; Lplunc3
Summary: Predicted to enable lipid binding activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm. Is expressed in testis. Orthologous to human BPIFB3 (BPI fold containing family B member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 2.3), mammary gland adult (RPKM 0.8) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.99 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153760118..153774916)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153918198..153932996)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BPI fold-containing family B member 3

Names: antimicrobial peptide RYA3; ligand-binding protein RYA3; long palate, lung and nasal epithelium carcinoma-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379473.1 → NP_001366402.1 BPI fold-containing family B member 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL833803

UniProtKB/Swiss-Prot

A2APD1, Q80ZU7

Related

ENSMUSP00000105382.2, ENSMUST00000109760.2

Conserved Domains (2) summary

smart00329
Location:273 → 471

BPI2; BPI/LBP/CETP C-terminal domain

cl00188
Location:26 → 249

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
NM_194357.2 → NP_919338.2 BPI fold-containing family B member 3 precursor

See identical proteins and their annotated locations for NP_919338.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL833803

Consensus CDS

CCDS16921.1

UniProtKB/Swiss-Prot

A2APD1, Q80ZU7

Related

ENSMUSP00000086342.2, ENSMUST00000088950.8

Conserved Domains (2) summary

smart00329
Location:273 → 471

BPI2; BPI/LBP/CETP C-terminal domain

cl00188
Location:26 → 249

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...